| UniProt ID | NUCB1_RAT | |
|---|---|---|
| UniProt AC | Q63083 | |
| Protein Name | Nucleobindin-1 | |
| Gene Name | Nucb1 | |
| Organism | Rattus norvegicus (Rat). | |
| Sequence Length | 459 | |
| Subcellular Localization |
Golgi apparatus, cis-Golgi network membrane Peripheral membrane protein Lumenal side . Cytoplasm . Secreted . A small fraction of the protein may be cytoplasmic. In bone at least part of it is found in the extracellular matrix and in the culture |
|
| Protein Description | Major calcium-binding protein of the Golgi. May have a role in calcium homeostasis.. | |
| Protein Sequence | MPTSVPRGAPFLLLPPLLMLSAVLAVPVDRAAPHQEDNQATETPDTGLYYHRYLQEVINVLETDGHFREKLQAANAEDIKSGKLSQELDFVSHNVRTKLDELKRQEVSRLRMLLKAKMDAKQEPNLQVDHMNLLKQFEHLDPQNQHTFEARDLELLIQTATRDLAQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKLQEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGETAEGWKTVEMYPAYTEEELKRFEEELAAREAELNARAQRLSQETEALGRSQDRLEAQKRELQQAVLQMEQRKQQQQEQSAPPSQPDGQLQFRADTGDAPVPAPAGDQKDVPASEKKVPEQPPVLPQLDSQHL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 81 | Phosphorylation | ANAEDIKSGKLSQEL CCHHHHHCCCCCHHH | 41.30 | 27097102 | |
| 85 | Phosphorylation | DIKSGKLSQELDFVS HHHCCCCCHHHHHHH | 25.70 | 23712012 | |
| 92 | Phosphorylation | SQELDFVSHNVRTKL CHHHHHHHHHHHHHH | 14.88 | 28689409 | |
| 147 | Phosphorylation | LDPQNQHTFEARDLE CCCCCCCCCHHHHHH | 17.26 | - | |
| 176 | Acetylation | AAHHEEFKRYEMLKE HHCHHHHHHHHHHHH | 58.30 | 22902405 | |
| 223 | Phosphorylation | PKVNVPGSQAQLKEV CCCCCCCCHHHHHHH | 19.10 | 28432305 | |
| 319 | Phosphorylation | TLEEFLASTQRKEFG HHHHHHHHHCHHHHC | 27.50 | 28432305 | |
| 320 | Phosphorylation | LEEFLASTQRKEFGE HHHHHHHHCHHHHCC | 27.13 | 28432305 | |
| 368 | Phosphorylation | NARAQRLSQETEALG HHHHHHHHHHHHHHH | 28.32 | 23712012 | |
| 371 | Phosphorylation | AQRLSQETEALGRSQ HHHHHHHHHHHHCCH | 20.94 | 16641100 | |
| 456 | Phosphorylation | PVLPQLDSQHL---- CCCCCCCCCCC---- | 28.26 | 28689409 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NUCB1_RAT !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NUCB1_RAT !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NUCB1_RAT !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of NUCB1_RAT !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| Phosphorylation | |
| Reference | PubMed |
| "Quantitative phosphoproteomics of vasopressin-sensitive renal cells:regulation of aquaporin-2 phosphorylation at two sites."; Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.; Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-81; SER-85; SER-368 ANDTHR-371, AND MASS SPECTROMETRY. | |
