NU155_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NU155_RAT
• UniProt AC: P37199
• Protein Name: Nuclear pore complex protein Nup155
• Gene Name: Nup155
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1390
• Subcellular Localization: Nucleus, nuclear pore complex . Nucleus membrane ; Peripheral membrane protein ; Cytoplasmic side . Nucleus membrane ; Peripheral membrane protein ; Nucleoplasmic side . In mitosis, assumes a diffuse cytoplasmic distribution probably as a monomer, be
• Protein Description: Essential component of nuclear pore complex. Could be essessential for embryogenesis (By similarity). Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport..
• Protein Sequence: MPSMLGSMMVASTSAPSLQEALENAGRLIDRQLQEDRMYPDLSELLMVSAPNSPTVSGMSDMDYPLQGPGLLSVPSLPEISTIRRVPLRLSWLNSLDTCSVTAMMGVFPPISRAWLTIDSDIFMWNYEDGGDLAYFDGLSETILAVGLVKPKAGIFQPHVRHLLVLATPVDIVILGLSYANVQTGSGILNDSVCGGLQLLPDPLYSLPTDNTYLLTITSTDNGRIFLAGKDGCLYEVAYQAEAGWFSQRCRKINHSKSSLSFLVPSLLQFTFSEDDPIVQIEIDNSRNILYTRSEKGVIQVYDLGHDGQGMSRVASVSQNAIVCAAGNIARTIDRSVFKPIVQIAVIENSESLDCQLLAVTHAGVRLYFSTCPFRQPLARPNTLTLVHVRLPPGFSASSTVEKPSKVHKALYSKGILLMTASENEDNDILWCVNHDTFPFQKPMMETQMTTRVDGHSWALSAIDELKVDKIITPLNKDHIPITDSPVVVQQHMLPPKKFVLLSAQGSLMFHKLRPVDQLRHLLVSNVGGDGEEIERFFKLHQEDQACATCLILACSTAACDREVSAWATRAFFRYGGEAQMRFPATLPTPSNVGPILGSPMYSSSPVPTGSPYPNPSSLGTPSHGAQPPTMSTPMSAVGNPAMQAASLSGLTGPEIVYSGKHNGICIYFSRIMGNIWDASLVVERVFKSSNREITAIESSVPIQLLESVLQELKGLQEFLDRNSQFSGGPLGNPNTTAKVQQRLLGVMRPENGNTQQMQQELQRKFHEAQLSEKISLQAIQQLVRKSYQALALWKLLCEHQFTVIVGELQKEFQEQLKITTFKDLVIREKEVTGALIASLINCYIRDNAAVDGISLHLQDTCPLLYSTDDAVCSKANELLQRSRQVQSKSERERMLRESLKEYQKISNQVDLPSVCAQYRQVRFYEGVVELSLTAAEKKDPQGLGLHFYKHGEPEEDVVGLQTFQERLNSYKCITDTLQELVNQSKAAPQSPSVPKKPGPPVLSSDPNMLSNEEAGHHFEQMLKLAQRSKDELFSIALYNWLIQADLADKLLQIASPFLEPHLVRMAKVDQNRVRYMDLLWRYYEKNRSFSSAARVLSKLADMHSTEISLQQRLEYIARAILSAKSSTAISSIAADGEFLHELEEKMEVARIQLQIQETLQRQYSHHSSVQDAISQLDSELMDITKLYGEFADPFKLAECKLAIIHCAGYSDPILVHTLWQDIIEKELSDSVTLSSSDRMHALSLKLVLLGKIYAGTPRFFPLDFIVQFLEQQVCTLNWDVGFVIQTMNEIGVPLPRLLEVYDQLFKSRDPFWNRVKSPLHLLDCIHVLLTRYVENPSLVLNCERRRFTNLCLDAVCGYLVELQSMSSSVAVQAITGNFKSLQAKLERLH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
525	O-linked_Glycosylation	QLRHLLVSNVGGDGE HHHHHHHHCCCCCHH	26.26	12438562
739	Ubiquitination	GNPNTTAKVQQRLLG CCCCCHHHHHHHHHC	38.18	-
903	Phosphorylation	LRESLKEYQKISNQV HHHHHHHHHHHHHCC	17.33	-
991	Phosphorylation	QSKAAPQSPSVPKKP HHCCCCCCCCCCCCC	20.34	29779826
993	Phosphorylation	KAAPQSPSVPKKPGP CCCCCCCCCCCCCCC	57.19	27097102
997	Acetylation	QSPSVPKKPGPPVLS CCCCCCCCCCCCCCC	49.49	22902405
1056	Phosphorylation	DKLLQIASPFLEPHL HHHHHHHHHHCCHHH	20.15	-
1105	Phosphorylation	SKLADMHSTEISLQQ HHHHCCCCCCCCHHH	22.54	25575281
1106	Phosphorylation	KLADMHSTEISLQQR HHHCCCCCCCCHHHH	23.74	25575281
1109	Phosphorylation	DMHSTEISLQQRLEY CCCCCCCCHHHHHHH	17.56	25575281

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NU155_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NU155_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NU155_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of NU155_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

O-linked Glycosylation

"Mapping sites of O-GlcNAc modification using affinity tags for serineand threonine post-translational modifications.";
Wells L., Vosseller K., Cole R.N., Cronshaw J.M., Matunis M.J.,Hart G.W.;
Mol. Cell. Proteomics 1:791-804(2002).
Cited for: GLYCOSYLATION AT SER-525.
PubMed: 12438562