NT5M_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NT5M_HUMAN
• UniProt AC: Q9NPB1
• Protein Name: 5'(3')-deoxyribonucleotidase, mitochondrial
• Gene Name: NT5M
• Organism: Homo sapiens (Human).
• Sequence Length: 228
• Subcellular Localization: Mitochondrion .
• Protein Description: Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP..
• Protein Sequence: MIRLGGWCARRLCSAAVPAGRRGAAGGLGLAGGRALRVLVDMDGVLADFEGGFLRKFRARFPDQPFIALEDRRGFWVSEQYGRLRPGLSEKAISIWESKNFFFELEPLPGAVEAVKEMASLQNTDVFICTSPIKMFKYCPYEKYAWVEKYFGPDFLEQIVLTRDKTVVSADLLIDDRPDITGAEPTPSWEHVLFTACHNQHLQLQPPRRRLHSWADDWKAILDSKRPC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
120	Phosphorylation	EAVKEMASLQNTDVF HHHHHHHHCCCCCEE	29.22	-
124	Phosphorylation	EMASLQNTDVFICTS HHHHCCCCCEEEECC	22.15	-
137	Acetylation	TSPIKMFKYCPYEKY CCCCCCHHCCCHHHH	42.31	25953088
166	Phosphorylation	IVLTRDKTVVSADLL HHHCCCCEEEEEEEE	30.35	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NT5M_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NT5M_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NT5M_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of NT5M_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.