NSMA2_RAT - dbPTM
NSMA2_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NSMA2_RAT
UniProt AC O35049
Protein Name Sphingomyelin phosphodiesterase 3
Gene Name Smpd3
Organism Rattus norvegicus (Rat).
Sequence Length 655
Subcellular Localization Golgi apparatus membrane
Lipid-anchor . Cell membrane
Lipid-anchor . May localize to detergent-resistant subdomains of Golgi membranes of hypothalamic neurosecretory neurons (PubMed:10823942).
Protein Description Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Acts as a regulator of postnatal development and participates in bone and dentin mineralization. Overexpression enhances cell death, suggesting that it may be involved in apoptosis control. May be involved in IL-1-beta-induced JNK activation in hepatocytes. May act as a mediator in transcriptional regulation of NOS2/iNOS via the NF-kappa-B activation under inflammatory conditions..
Protein Sequence MVLYTTPFPNSCLSALHAVSWALIFPCYWLVDRLVASFIPTTYEKRQRADDPCYLQLFCTVLFTPVYLALLVAALPFAFLGFIFWSPLQSARRPYSYSRLEDKSPAGGAALLSEWKGTGAGKSFCFATANVCLLPDSLARLNNVFNTQARAKEIGQRIRNGAARPQIKIYIDSPTNTSISAASFSSLVSPQGSDGARAVPGSIKRTASVEYKGDGGRHPSDEAANGPASGEQADGSLEDSCIVRIGGEEGGRAQEADDPAPGSQARNGAGGTPKGQTPNHNQRDGDSGSLGSPSASRESLVKARAGQDSGGSGEPGSNSKLLYKTSVVKKAAARRRRHPDEAFDHEVSAFFPANLDFLCLQEVFDKRAAAKLKEQLHGYFEYILYDVGVYGCHGCCNFKCLNSGLFFASRYPVMDVAYHCYPNGCSFDALASKGALFLKVQVGSTPQDQRIVGYIACTHLHAPPEDSAIRCEQLDLLQDWLADFRKSTSSTSTANPEELVVFDVICGDLNFDNCSSDDKLEQQHSLFTRYKDPCRLGPGEEKPWAIGTLLDINGLYDEDVCTPDNLQKVLESEEGRREYLAFPTSKSPGAGQKGRKDLLKGNGRRIDYMLHAEEGLCPDWKAEVEEFSFITQLSGLTDHLPVAMRLMVSAGEEEA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
45UbiquitinationFIPTTYEKRQRADDP
HCCCHHHHHHCCCCC		43.34-
53S-palmitoylationRQRADDPCYLQLFCT
HHCCCCCHHHHHHHH		7.33-
59S-palmitoylationPCYLQLFCTVLFTPV
CHHHHHHHHHHHHHH		3.32-
103UbiquitinationSYSRLEDKSPAGGAA
CCCCCCCCCCCCCHH		49.30-
116UbiquitinationAALLSEWKGTGAGKS
HHHHHCCCCCCCCCC		42.41-
170PhosphorylationARPQIKIYIDSPTNT
CCCCEEEEEECCCCC		8.1527097102
173PhosphorylationQIKIYIDSPTNTSIS
CEEEEEECCCCCCEE		24.8627097102
175PhosphorylationKIYIDSPTNTSISAA
EEEEECCCCCCEEHH		55.8927097102
177PhosphorylationYIDSPTNTSISAASF
EEECCCCCCEEHHHH		29.8927097102
178PhosphorylationIDSPTNTSISAASFS
EECCCCCCEEHHHHH		19.3327097102
180PhosphorylationSPTNTSISAASFSSL
CCCCCCEEHHHHHHH		19.9727097102
183PhosphorylationNTSISAASFSSLVSP
CCCEEHHHHHHHCCC		25.9427097102
185PhosphorylationSISAASFSSLVSPQG
CEEHHHHHHHCCCCC		21.9227097102
186PhosphorylationISAASFSSLVSPQGS
EEHHHHHHHCCCCCC		30.6827097102
189PhosphorylationASFSSLVSPQGSDGA
HHHHHHCCCCCCCCC		19.4628551015
202PhosphorylationGARAVPGSIKRTASV
CCCCCCCCCEEEEEE		20.9021630457
206PhosphorylationVPGSIKRTASVEYKG
CCCCCEEEEEEEEEC		20.4825403869
208PhosphorylationGSIKRTASVEYKGDG
CCCEEEEEEEEECCC		18.1829779826
211PhosphorylationKRTASVEYKGDGGRH
EEEEEEEEECCCCCC		20.3722668510
220PhosphorylationGDGGRHPSDEAANGP
CCCCCCCCHHHCCCC		41.7927097102
229PhosphorylationEAANGPASGEQADGS
HHCCCCCCCCCCCCC		46.1022668510
236PhosphorylationSGEQADGSLEDSCIV
CCCCCCCCCCCCEEE		29.1827097102
287PhosphorylationHNQRDGDSGSLGSPS
CCCCCCCCCCCCCCC		35.4927097102
289PhosphorylationQRDGDSGSLGSPSAS
CCCCCCCCCCCCCCC		33.2427097102
292PhosphorylationGDSGSLGSPSASRES
CCCCCCCCCCCCHHH		22.4527097102
294PhosphorylationSGSLGSPSASRESLV
CCCCCCCCCCHHHHH		40.3427097102
296PhosphorylationSLGSPSASRESLVKA
CCCCCCCCHHHHHHH		40.7027097102
299PhosphorylationSPSASRESLVKARAG
CCCCCHHHHHHHHCC		37.0327097102
317PhosphorylationGGSGEPGSNSKLLYK
CCCCCCCCCCCEEEH		48.9628432305
323PhosphorylationGSNSKLLYKTSVVKK
CCCCCEEEHHHHHHH		23.7425575281
325PhosphorylationNSKLLYKTSVVKKAA
CCCEEEHHHHHHHHH		17.1328432305
326PhosphorylationSKLLYKTSVVKKAAA
CCEEEHHHHHHHHHH		22.2925403869
395S-palmitoylationGVYGCHGCCNFKCLN
CCCCCCCCCCCEECC		0.51-
396S-palmitoylationVYGCHGCCNFKCLNS
CCCCCCCCCCEECCC		8.75-
586UbiquitinationYLAFPTSKSPGAGQK
EECCCCCCCCCCCCC		64.25-
587PhosphorylationLAFPTSKSPGAGQKG
ECCCCCCCCCCCCCC		28.4725403869
600UbiquitinationKGRKDLLKGNGRRID
CCCHHHHCCCCCCCC		58.59-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NSMA2_RAT !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NSMA2_RAT !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NSMA2_RAT !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of NSMA2_RAT !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NSMA2_RAT

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Related Literatures of Post-Translational Modification

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