NSG1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NSG1_RAT
• UniProt AC: P02683
• Protein Name: Neuronal vesicle trafficking-associated protein 1 {ECO:0000250|UniProtKB:P42857}
• Gene Name: Nsg1 {ECO:0000312|RGD:2222}
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 185
• Subcellular Localization: Membrane ; Single-pass type II membrane protein . Golgi apparatus, trans-Golgi network membrane . Endosome membrane . Cell projection, dendrite . Early endosome membrane . Late endosome membrane . Lysosome lumen . Recycling endosome membrane . Cytoplasmic
• Protein Description: Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. [PubMed: 18299352]
• Protein Sequence: MVKLGNNFAEKGTKQPLLEDGFDTIPLMTPLDVNQLQFPPPDKVVVKTKTEYEPDRKKGKARPPKIAEFTVSITEGVTERFKVSVLVLFALAFLTCVVFLVVYKVYKYDRACPDGFVLKNTQCIPEGLESYYTEQDSSAREKFYTVINHYNLAKQSITRSVSPWMSVLSEEKLSEQETEAAEKSA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Ubiquitination	LGNNFAEKGTKQPLL CCCCCCCCCCCCCCC	69.33	-
14	Ubiquitination	NFAEKGTKQPLLEDG CCCCCCCCCCCCCCC	59.60	-
160	Phosphorylation	AKQSITRSVSPWMSV HHHHHHHCCCHHHHH	20.49	25575281
162	Phosphorylation	QSITRSVSPWMSVLS HHHHHCCCHHHHHHC	17.68	25575281
166	Phosphorylation	RSVSPWMSVLSEEKL HCCCHHHHHHCHHHH	18.95	25575281
169	Phosphorylation	SPWMSVLSEEKLSEQ CHHHHHHCHHHHCHH	41.37	28432305
174	Phosphorylation	VLSEEKLSEQETEAA HHCHHHHCHHHHHHH	48.58	25575281
178	Phosphorylation	EKLSEQETEAAEKSA HHHCHHHHHHHHHHC	30.53	25575281

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NSG1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NSG1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NSG1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of NSG1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.