NSE2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NSE2_ARATH
• UniProt AC: Q8GYH7
• Protein Name: E3 SUMO-protein ligase MMS21
• Gene Name: MMS21
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 249
• Subcellular Localization: Nucleus . Cytoplasm .
• Protein Description: E3 SUMO-protein ligase that modulates cell cycle progression and functions as a repressor of endocycle onset in meristems. May function downstream of the meristem patterning transcription factors PLETHORA 1 and 2 (PLT1 and PLT2) in root meristem development. Modulates the expression of the mitotic cyclins CYCB1-1 and CYCB1-2 and cyclin-dependent kinases CDKB1-1 and CDKB2-1 in root meristem. Involved in cytokinin signaling in root development..
• Protein Sequence: MASASSSDGVAGRIQNASLVLVSDNSSTLADIRKAVAMMKNIAVQLEKENQTDKVKDLENSVAELLDLHSDCNHRSTAIQSVANRYQPVEQLTDFKKLLDDEFTKLKATPSSVPQNDHLMRQFREAVWNVHHAGEPMPGDDDEDIVMTSTQCPLLNMTCPLSGKPVTELADPVRSMDCRHVYEKSVILHYIVNNPNANCPVAGCRGKLQNSKVICDAMLKFEIEEMRSLNKQSNRAEVIEDFTEDVDED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASASSSDG ------CCCCCCCCC	17.50	22223895

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NSE2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NSE2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NSE2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SCE1_ARATH	SCE1	physical	19682286

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.