NRG2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NRG2_HUMAN
• UniProt AC: O14511
• Protein Name: Pro-neuregulin-2, membrane-bound isoform
• Gene Name: NRG2
• Organism: Homo sapiens (Human).
• Sequence Length: 850
• Subcellular Localization: Pro-neuregulin-2, membrane-bound isoform: Cell membrane; Single-pass type I membrane protein. Does not seem to be active..; Neuregulin-2: Secreted.
• Protein Description: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor..
• Protein Sequence: MRQVCCSALPPPPLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPAAPPEPRPQQQPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACYSPSLKSVQDQAYKAPVVVEGKVQGLVPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVISVGSCVPLERNQRYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEVGKILCTDCATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKCPNGFFGQRCLEKLPLRLYMPDPKQKAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYHDSVDSLRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDSHSTRASSRHSRGPPPRAKQDSAPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	LEKGRCSSYSDSSSS CCCCCCCCCCCCCCC	32.08	-
23	Phosphorylation	KGRCSSYSDSSSSSS CCCCCCCCCCCCCCC	32.72	-
27	Phosphorylation	SSYSDSSSSSSERSS CCCCCCCCCCCCCCC	37.89	-
30	Phosphorylation	SDSSSSSSERSSSSS CCCCCCCCCCCCCCC	38.69	-
34	Phosphorylation	SSSSERSSSSSSSSS CCCCCCCCCCCCCCC	40.22	-
35	Phosphorylation	SSSERSSSSSSSSSE CCCCCCCCCCCCCCC	35.17	-
36	Phosphorylation	SSERSSSSSSSSSES CCCCCCCCCCCCCCC	35.87	-
37	Phosphorylation	SERSSSSSSSSSESG CCCCCCCCCCCCCCC	35.87	-
38	Phosphorylation	ERSSSSSSSSSESGS CCCCCCCCCCCCCCC	35.87	-
45	Phosphorylation	SSSSESGSSSRSSSN CCCCCCCCCCCCCCC	34.13	-
47	Phosphorylation	SSESGSSSRSSSNNS CCCCCCCCCCCCCCC	37.57	-
52	N-linked_Glycosylation	SSSRSSSNNSSISRP CCCCCCCCCCCCCCC	55.11	UniProtKB CARBOHYD
53	N-linked_Glycosylation	SSRSSSNNSSISRPA CCCCCCCCCCCCCCC	38.80	UniProtKB CARBOHYD
54	Phosphorylation	SRSSSNNSSISRPAA CCCCCCCCCCCCCCC	33.04	26074081
55	Phosphorylation	RSSSNNSSISRPAAP CCCCCCCCCCCCCCC	27.06	26074081
57	Phosphorylation	SSNNSSISRPAAPPE CCCCCCCCCCCCCCC	33.87	26074081
147	N-linked_Glycosylation	PAGGSSSNSTREPPA ECCCCCCCCCCCCCC	49.72	UniProtKB CARBOHYD
194	Phosphorylation	PLERNQRYIFFLEPT ECCCCCEEEEEECCC	7.72	-
278	N-linked_Glycosylation	FKDGKELNRSRDIRI CCCCCCCCCCCCEEE	40.76	UniProtKB CARBOHYD
287	Phosphorylation	SRDIRIKYGNGRKNS CCCEEEECCCCCCCC	17.29	24719451
287 (in isoform 3)	Phosphorylation	-	17.29	24719451
294	Phosphorylation	YGNGRKNSRLQFNKV CCCCCCCCCEEECCE	37.09	24719451
294 (in isoform 3)	Phosphorylation	-	37.09	24719451
333	O-linked_Glycosylation	LYVNSVSTTLSSWSG EEEEECCCCHHHCCC	29.60	55833591
334	O-linked_Glycosylation	YVNSVSTTLSSWSGH EEEECCCCHHHCCCC	19.69	55833593
346	N-linked_Glycosylation	SGHARKCNETAKSYC CCCCCCCCCCHHHHH	53.33	UniProtKB CARBOHYD
459	Phosphorylation	RSLANGPSHPRLDPE HHHCCCCCCCCCCHH	47.74	29396449
475	Phosphorylation	IQMADYISKNVPATD HHHHHHHHCCCCCCC	16.37	30631047
549	Phosphorylation	VGTSKCNSPACVEAR CCCCCCCCHHHHHHH	24.28	24719451
557 (in isoform 3)	Phosphorylation	-	16.62	24719451
579	Phosphorylation	TAPPYHDSVDSLRDS CCCCCCCCHHHHHCC	17.95	-
582	Phosphorylation	PYHDSVDSLRDSPHS CCCCCHHHHHCCCCC	24.13	-
686 (in isoform 3)	Phosphorylation	-	26.40	27642862
767	Phosphorylation	RDSLSLSSGSGGGSA HHHCCCCCCCCCCCC	42.12	-
807	Phosphorylation	GAHDALRSDSPPLCP CHHHHHHCCCCCCCC	43.20	29449344
809	Phosphorylation	HDALRSDSPPLCPAA HHHHHCCCCCCCCCC	29.66	28348404
820	Phosphorylation	CPAADSRTYYSLDSH CCCCCCCCEEECCCC	30.66	25219547
821	Phosphorylation	PAADSRTYYSLDSHS CCCCCCCEEECCCCC	7.02	25219547
822	Phosphorylation	AADSRTYYSLDSHST CCCCCCEEECCCCCC	11.35	25219547
823	Phosphorylation	ADSRTYYSLDSHSTR CCCCCEEECCCCCCC	18.45	25219547
826	Phosphorylation	RTYYSLDSHSTRASS CCEEECCCCCCCCHH	25.32	25219547
828	Phosphorylation	YYSLDSHSTRASSRH EEECCCCCCCCHHCC	24.44	25219547
829	Phosphorylation	YSLDSHSTRASSRHS EECCCCCCCCHHCCC	25.49	25219547
837	Methylation	RASSRHSRGPPPRAK CCHHCCCCCCCCCCC	56.35	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NRG2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NRG2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NRG2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ERBB4_HUMAN	ERBB4	physical	9168115
ERBB3_HUMAN	ERBB3	physical	9168115

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.