NRF1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NRF1_MOUSE
• UniProt AC: Q9WU00
• Protein Name: Nuclear respiratory factor 1
• Gene Name: Nrf1
• Organism: Mus musculus (Mouse).
• Sequence Length: 503
• Subcellular Localization: Nucleus.
• Protein Description: Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication (By similarity)..
• Protein Sequence: MEEHGVTQTEHMATIEAHAVAQQVQQVHVATYTEHSMLSADEDSPSSPEDTSYDDSDILNSTAADEVTAHLAAAGPVGMAAAAAVATGKKRKRPHVFESNPSIRKRQQTRLLRKLRATLDEYTTRVGQQAIVLCISPSKPNPVFKVFGAAPLENVVRKYKSMILEDLESALAEHAPAPQEVNSELPPLTIDGIPVSVDKMTQAQLRAFIPEMLKYSTGRGKPGWGKESCKPIWWPEDIPWANVRSDVRTEEQKQRVSWTQALRTIVKNCYKQHGREDLLYAFEDQQTQTQATTTHSIAHLVPSQTVVQTFSNPDGTVSLIQVGTGATVATLADASELPTTVTVAQVNYSAVADGEVEQNWATLQGGEMTIQTTQASEATQAVASLAEAAVAASQEMQQGATVTMALNSEAAAHAVATLAEATLQGGGQIVLSGETAAAVGALTGVQDANGLVQIPVSMYQTVVTSLAQGNGPVQVAMAPVTTRISDSAVTMDGQAVEVVTLEQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Phosphorylation	YTEHSMLSADEDSPS ECCCCCCCCCCCCCC	25.65	-
44	Phosphorylation	MLSADEDSPSSPEDT CCCCCCCCCCCCCCC	25.32	-
46	Phosphorylation	SADEDSPSSPEDTSY CCCCCCCCCCCCCCC	63.58	-
47	Phosphorylation	ADEDSPSSPEDTSYD CCCCCCCCCCCCCCC	35.38	-
52	Phosphorylation	PSSPEDTSYDDSDIL CCCCCCCCCCHHHHC	38.60	-
56	Phosphorylation	EDTSYDDSDILNSTA CCCCCCHHHHCCCCC	24.53	-
99	Phosphorylation	KRPHVFESNPSIRKR CCCCCCCCCHHHHHH	42.44	28059163
122	Phosphorylation	LRATLDEYTTRVGQQ HHHHHHHHHHHHCCE	17.05	24899341
136	Phosphorylation	QAIVLCISPSKPNPV EEEEEEECCCCCCCC	23.32	25159016
138	Phosphorylation	IVLCISPSKPNPVFK EEEEECCCCCCCCCE	54.69	25159016
215	Phosphorylation	FIPEMLKYSTGRGKP HHHHHHHHCCCCCCC	13.91	28059163
217	Phosphorylation	PEMLKYSTGRGKPGW HHHHHHCCCCCCCCC	28.01	28059163

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
39	S	Phosphorylation	Kinase	CK2	-	Uniprot
44	S	Phosphorylation	Kinase	CK2	-	Uniprot
46	S	Phosphorylation	Kinase	CK2	-	Uniprot
47	S	Phosphorylation	Kinase	CK2	-	Uniprot
52	S	Phosphorylation	Kinase	CK2	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NRF1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NRF1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NRF1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.