NRBF2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NRBF2_MOUSE
• UniProt AC: Q8VCQ3
• Protein Name: Nuclear receptor-binding factor 2
• Gene Name: Nrbf2
• Organism: Mus musculus (Mouse).
• Sequence Length: 287
• Subcellular Localization: Nucleus . Cytoplasm . Cytoplasmic vesicle, autophagosome .
• Protein Description: May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro) (By similarity).; Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy (By similarity). Stabilzes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3. [PubMed: 24849286 Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1 (By similarity May be involved in autophagosome biogenesis (By similarity May play a role in neural progenitor cell survival during differentiation]
• Protein Sequence: MEVMEGPLNLAHQQSRRADRLLAAGKYEEAISCHRKATTYLSEAMKLTESEQAHLSLELQRDSHMKQLLLIQERWKRAKREERLKAQQSTERDGAPHLQAPPRPSEDAEGQSPLLSQPYIPSTERRLPEVQGVFDRDPDTLLFLLQQKNEPSEPCIGSKAPKDDKTIIEEQATKIADLKRHVEFLVAENERLRKENKQLKAEKARLLKGTAEKELDVDADFVEKSELWGLPSHSESAAASSTWQKFAANTGKAKDIPIPNLPPLDFPSPELPLMELSEDILKGFMND

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	Phosphorylation	ISCHRKATTYLSEAM HHHHHHHHHHHHHHH	21.00	-
39	Phosphorylation	SCHRKATTYLSEAMK HHHHHHHHHHHHHHH	27.59	-
40	Phosphorylation	CHRKATTYLSEAMKL HHHHHHHHHHHHHHC	12.13	-
89	Phosphorylation	ERLKAQQSTERDGAP HHHHHHHHCCCCCCC	21.84	28285833
90	Phosphorylation	RLKAQQSTERDGAPH HHHHHHHCCCCCCCC	30.60	25338131
105	Phosphorylation	LQAPPRPSEDAEGQS CCCCCCCCCCCCCCC	49.76	29899451
112	Phosphorylation	SEDAEGQSPLLSQPY CCCCCCCCCCCCCCC	28.50	25521595
152	Phosphorylation	LQQKNEPSEPCIGSK HHCCCCCCCCCCCCC	48.25	28059163
225	Phosphorylation	DADFVEKSELWGLPS CCHHHCHHHHHCCCC	25.15	25777480
232	Phosphorylation	SELWGLPSHSESAAA HHHHCCCCCCCHHHH	44.69	25777480
234	Phosphorylation	LWGLPSHSESAAASS HHCCCCCCCHHHHHH	37.27	25777480
236	Phosphorylation	GLPSHSESAAASSTW CCCCCCCHHHHHHHH	26.65	25777480
240	Phosphorylation	HSESAAASSTWQKFA CCCHHHHHHHHHHHH	24.47	25777480
241	Phosphorylation	SESAAASSTWQKFAA CCHHHHHHHHHHHHH	29.01	25777480
242	Phosphorylation	ESAAASSTWQKFAAN CHHHHHHHHHHHHHH	29.44	25777480
250	Phosphorylation	WQKFAANTGKAKDIP HHHHHHHCCCCCCCC	35.02	22942356
268	Phosphorylation	LPPLDFPSPELPLME CCCCCCCCCCCCHHH	30.88	26824392

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NRBF2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NRBF2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NRBF2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NRBF2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.