NRAP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NRAP_HUMAN
• UniProt AC: Q86VF7
• Protein Name: Nebulin-related-anchoring protein
• Gene Name: NRAP {ECO:0000312|HGNC:HGNC:7988}
• Organism: Homo sapiens (Human).
• Sequence Length: 1730
• Subcellular Localization: Localized at the myotendinous junction in skeletal muscle and at the intercalated disk in cardiac muscle.
• Protein Description: May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix..
• Protein Sequence: MNVQPCSRCGYGVYPAEKISCIDQIWHKACFHCEVCKMMLSVNNFVSHQKKPYCHAHNPKNNTFTSVYHTPLNLNVRTFPEAISGIHDQEDGEQCKSVFHWDMKSKDKEGAPNRQPLANERAYWTGYGEGNAWCPGALPDPEIVRMVEARKSLGEEYTEDYEQPRGKGSFPAMITPAYQRAKKANQLASQVEYKRGHDERISRFSTVVDTPELLRSKAGAQLQSDVRYTEDYEQQRGKGSFPAMITPAYQIAKRANELASDVRYHQQYQKEMRGMAGPAIGAEGILTRECADQYGQGYPEEYEEHRGKGSFPAMITPAYQNAKKAHELASDIKYRQDFNKMKGAAHYHSLPAQDNLVLKQAQSVNKLVSEVEYKKDLESSRGHSINYCETPQFRNVSKISKFTSDNKYKENYQNHMRGRYEGVGMDRRTLHAMKVGSLASNVAYKADYKHDIVDYNYPATLTPSYQTAMKLVPLKDANYRQSIDKLKYSSVTDTPQIVQAKINAQQLSHVNYRADYEKNKLNYTLPQDVPQLVKAKTNAKLFSEVKYKEGWEKTKGKGFEMKLDAMSLLAAKASGELASNIKYKEEYEKTKGKAMGTADSRLLHSLQIAKMSSEVEYKKGFEESKTRFHLPMDMVNIRHAKKAQTLASDLDYRKKLHEYTVLPEDMKTQWAKKAYGLQSELQYKADLAWMKGVGWLTEGSLNLEQAKKAGQLVSEKNYRQRVDELKFTSVTDSSQMEHAKKSQELQSGVAYKAGNEQSVHQYTISKDEPLFLQARANAANLSEKLYKSSWENQKAKGFELRLDSLTFLAAKAKRDLASEVKYKEDYERSRGKLIGAKDVQGDSQMSHSLQMSKLQSELEYKKGFEDTKSQCHVSLDMVHLVHARKAQHLATDVGYKTAEHHFTALPTDMKVEWAKKAYGLQSDNQYRADVKWMKGMGWVATGSLNVEQAKKAGELISEKKYRQHPDALKFTSIKDTPEMVQARISYTQAVDRLYREQGENIKHHYTPTADLPEVLLAKLNAMNISETRYKESWSKLRDGGYKLRLDALPFQAAKASGEIISDYKYKEAFEKMKGQMLGSRSLEDDISLAHSVYATSLQSDVNYKKGFEHSKAQFHLPLDMAALVHAKKAQTLASNQDYKHPLPQYTSLAEDLRLSCAKKAHKLQSENLYRSDLNFMRGVACVIPGTLEIEGRKKASELISESKYRQHPHSFKYTAVTDTPNLLHAKFSNQITNERLYKAAGEDARHEYTMTLGLPEFIRAKTNAANLSDARYKESWRNLRAQGYKLTIEALPFQAARASGDIASDFLYRHDFVKERGKLIGPQSVRDDPRIQHCRRMGQLQSELQYRRGATSSQAQFHLPMDMVHLVHAKNAQALASDHDYRTQYHKFTALPEDLKMAWAKKAHALQSELRYKSDLIGMKGIGWLALRSPQMESAKKAGELISETKYRKKPDSIKFTTVVDSPDLVHAKNSYMHCNERMYRSGDAESLHRYTLIPDHPDFTRARLNALHLSDKVYRNSWEQTRAGSYDFRLDAIPFQTARASREIASDFRYKEAFLRDRGLQIGYRSVDDDPRMKHFLNVGRLQSDNEYKKDFAKSRSQFHSSTDQPGLLQAKRSQQLASDVHYRQPLPQPTCDPEQLGLRHAQKAHQLQSDVKYKSDLNLTRGVGWTPPGSYKVEMARRAAELANARGLGLQGAYRGAEAVEAGDHQSGEVNPDATEILHVKKKKALLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	Phosphorylation	EVCKMMLSVNNFVSH HHHHHHHHHCCHHHH	12.61	26552605
47	Phosphorylation	LSVNNFVSHQKKPYC HHHCCHHHHCCCCCC	18.96	26552605
53	Phosphorylation	VSHQKKPYCHAHNPK HHHCCCCCCCCCCCC	13.02	18083107
65	Phosphorylation	NPKNNTFTSVYHTPL CCCCCCEEEEEECCC	18.42	-
66	Phosphorylation	PKNNTFTSVYHTPLN CCCCCEEEEEECCCC	19.25	-
68	Phosphorylation	NNTFTSVYHTPLNLN CCCEEEEEECCCCCC	10.35	18083107
152	Phosphorylation	RMVEARKSLGEEYTE HHHHHHHHHCCCCCC	35.73	19764811
161	Phosphorylation	GEEYTEDYEQPRGKG CCCCCCCCCCCCCCC	15.38	-
169	Phosphorylation	EQPRGKGSFPAMITP CCCCCCCCCCHHCCH	31.38	-
194	Acetylation	LASQVEYKRGHDERI HHHHHHHHCCCCHHH	38.10	30590907
205	Phosphorylation	DERISRFSTVVDTPE CHHHHHHEEECCCHH	21.12	-
206	Phosphorylation	ERISRFSTVVDTPEL HHHHHHEEECCCHHH	23.10	-
210	Phosphorylation	RFSTVVDTPELLRSK HHEEECCCHHHHHHH	13.67	-
224	Phosphorylation	KAGAQLQSDVRYTED HHCCHHHCCCCCCHH	46.82	22985185
310	Phosphorylation	EEHRGKGSFPAMITP HHHCCCCCCCCCCCH	31.38	-
316	Phosphorylation	GSFPAMITPAYQNAK CCCCCCCCHHHHHHH	6.70	-
330	Phosphorylation	KKAHELASDIKYRQD HHHHHHHHHCCHHHH	53.12	-
334	Phosphorylation	ELASDIKYRQDFNKM HHHHHCCHHHHHHHC	17.53	-
373 (in isoform 3)	Phosphorylation	-	28.63	-
373 (in isoform 4)	Phosphorylation	-	28.63	-
384	Phosphorylation	LESSRGHSINYCETP HHHCCCCCCCEECCC	18.49	29888752
387	Phosphorylation	SRGHSINYCETPQFR CCCCCCCEECCCCCC	7.04	29888752
390	Phosphorylation	HSINYCETPQFRNVS CCCCEECCCCCCCHH	20.87	29888752
397	Phosphorylation	TPQFRNVSKISKFTS CCCCCCHHHHHHHCC	28.02	29888752
400	Phosphorylation	FRNVSKISKFTSDNK CCCHHHHHHHCCCCH	26.00	29888752
429	Phosphorylation	GVGMDRRTLHAMKVG CCCCCHHHHHHHCHH	24.64	21964256
437	Phosphorylation	LHAMKVGSLASNVAY HHHHCHHHHHHCCCH	24.61	26437602
464	Phosphorylation	YPATLTPSYQTAMKL CCCCCCCCHHHHHHC	25.33	21253578
465	Phosphorylation	PATLTPSYQTAMKLV CCCCCCCHHHHHHCC	15.87	21253578
482	Phosphorylation	KDANYRQSIDKLKYS CCCCHHHHHCCCCCC	24.61	26437602
488	Phosphorylation	QSIDKLKYSSVTDTP HHHCCCCCCCCCCCH	19.33	26437602
490	Phosphorylation	IDKLKYSSVTDTPQI HCCCCCCCCCCCHHH	26.41	26437602
523	Phosphorylation	YEKNKLNYTLPQDVP HHHCCCCCCCCCCHH	21.79	18083107
590	O-linked_Glycosylation	YKEEYEKTKGKAMGT CHHHHHHHCCCCCCC	32.84	30379171
597	Phosphorylation	TKGKAMGTADSRLLH HCCCCCCCHHHHHHH	17.76	24719451
612	Phosphorylation	SLQIAKMSSEVEYKK HHHHHHHCCCCCHHH	23.73	24719451
613	Phosphorylation	LQIAKMSSEVEYKKG HHHHHHCCCCCHHHC	42.01	26437602
617	Phosphorylation	KMSSEVEYKKGFEES HHCCCCCHHHCCCCC	24.15	24719451
618	Acetylation	MSSEVEYKKGFEESK HCCCCCHHHCCCCCC	32.68	24889111
679	Phosphorylation	KKAYGLQSELQYKAD HHHHCCCHHHHHHHH	45.37	-
818	Phosphorylation	KAKRDLASEVKYKED HHHHHHHHHCCCHHH	50.66	23401153
843	Phosphorylation	AKDVQGDSQMSHSLQ CCCCCCCHHHHHHHH	34.31	26552605
846	Phosphorylation	VQGDSQMSHSLQMSK CCCCHHHHHHHHHHH	11.42	26552605
848	Phosphorylation	GDSQMSHSLQMSKLQ CCHHHHHHHHHHHHH	17.00	26552605
852	Phosphorylation	MSHSLQMSKLQSELE HHHHHHHHHHHHHHH	19.77	26552605
856	Phosphorylation	LQMSKLQSELEYKKG HHHHHHHHHHHHHHC	55.36	26552605
860	Phosphorylation	KLQSELEYKKGFEDT HHHHHHHHHHCCCCC	30.53	26552605
916	Acetylation	MKVEWAKKAYGLQSD CHHHHHHHHHCCCCC	38.81	20167786
934	Acetylation	RADVKWMKGMGWVAT HHCCCHHHCCCCEEE	44.63	11794901
957	Phosphorylation	KKAGELISEKKYRQH HHHHHHCCHHHHHCC	56.86	24719451
959	Sumoylation	AGELISEKKYRQHPD HHHHCCHHHHHCCCC	48.60	-
959	Sumoylation	AGELISEKKYRQHPD HHHHCCHHHHHCCCC	48.60	-
959	Acetylation	AGELISEKKYRQHPD HHHHCCHHHHHCCCC	48.60	11794913
971	Phosphorylation	HPDALKFTSIKDTPE CCCCCCCCCCCCCHH	28.14	27174698
972	Phosphorylation	PDALKFTSIKDTPEM CCCCCCCCCCCCHHH	30.67	27174698
976	Phosphorylation	KFTSIKDTPEMVQAR CCCCCCCCHHHHHHH	19.02	27174698
985	Phosphorylation	EMVQARISYTQAVDR HHHHHHHHHHHHHHH	19.30	21712546
986	Phosphorylation	MVQARISYTQAVDRL HHHHHHHHHHHHHHH	10.66	21712546
994	Phosphorylation	TQAVDRLYREQGENI HHHHHHHHHHCCCCC	17.01	22964224
1081	Phosphorylation	GQMLGSRSLEDDISL CCCCCCCCHHHHHHH	37.50	29978859
1087	Phosphorylation	RSLEDDISLAHSVYA CCHHHHHHHHHHHHH	26.88	29978859
1091	Phosphorylation	DDISLAHSVYATSLQ HHHHHHHHHHHHHCC	15.94	29978859
1093	Phosphorylation	ISLAHSVYATSLQSD HHHHHHHHHHHCCCC	13.74	29978859
1095	Phosphorylation	LAHSVYATSLQSDVN HHHHHHHHHCCCCCC	16.57	29978859
1096	Phosphorylation	AHSVYATSLQSDVNY HHHHHHHHCCCCCCC	19.08	29978859
1099	Phosphorylation	VYATSLQSDVNYKKG HHHHHCCCCCCCCCC	49.14	29978859
1103	Phosphorylation	SLQSDVNYKKGFEHS HCCCCCCCCCCCCCC	17.58	29978859
1214	Phosphorylation	HPHSFKYTAVTDTPN CCCCCCEEEECCCCC	18.42	-
1299	Phosphorylation	PFQAARASGDIASDF CHHHHHHCCCHHHHH	31.29	22210691
1308	Phosphorylation	DIASDFLYRHDFVKE CHHHHHHHCHHHHHH	13.09	22210691
1324	Phosphorylation	GKLIGPQSVRDDPRI CEECCCCCCCCCHHH	23.42	26437602
1383	Phosphorylation	ASDHDYRTQYHKFTA HCCCCHHHHHHHHCC	27.53	29052541
1385	Phosphorylation	DHDYRTQYHKFTALP CCCHHHHHHHHCCCH	13.33	29052541
1389	Phosphorylation	RTQYHKFTALPEDLK HHHHHHHCCCHHHHH	31.89	29052541
1482	Phosphorylation	CNERMYRSGDAESLH CCCCCCCCCCHHHHH	24.44	26437602
1487	Phosphorylation	YRSGDAESLHRYTLI CCCCCHHHHHHEECC	31.06	26437602
1518	Phosphorylation	SDKVYRNSWEQTRAG CCCHHHCCHHHHCCC	24.00	26437602
1598	Phosphorylation	KDFAKSRSQFHSSTD HHHHHHHHHHCCCCC	44.27	26437602
1603	Phosphorylation	SRSQFHSSTDQPGLL HHHHHCCCCCCCCHH	27.68	26437602

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NRAP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NRAP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NRAP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VINC_HUMAN	VCL	physical	10320340

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.