NRAM2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NRAM2_RAT
• UniProt AC: O54902
• Protein Name: Natural resistance-associated macrophage protein 2
• Gene Name: Slc11a2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 568
• Subcellular Localization: Endosome membrane ; Multi-pass membrane protein . Mitochondrion outer membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Also found in extracellular vesicles different from exosomes.
• Protein Description: May serve to import iron into the mitochondria (By similarity). Important in metal transport, in particular iron. Can also transport zinc, manganese, cobalt, cadmium, copper, nickel and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution..
• Protein Sequence: MVLDPEEKIPDDGASGDHGDSASLGAINPAYSNSSLPHSTGDSEEPFTTYFDEKIPIPEEEYSCFSFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWVLLLATIVGLLLQRLAARLGVVTGLHLAEVCHRQYPKVPRIILWLMVELAIIGSDMQEVIGSAIAINLLSAGRVPLYGGVLITIADTFVFLFLDKYGLRKLEAFFGFLITIMALTFGYEYVTVKPSQSQVLRGMFVPSCSGCHTPQVEQAVGIVGAVIMPHNMYLHSALVKSRQVNRANKQEVREANKYFFIESCIALFVSFIINVFVVSVFAEAFFEKTNEQVVEVCRNSSSPHADLFPNDNSTLAVDIYKGGVVLGCYFGPAALYIWAVGILAAGQSSTMTGTYSGQFVMEGFLNLKWSRFARVILTRSIAIIPTLLVAVFQDVEHLTGMNDFLNVLQSLQLPFALIPILTFTSLRPVMSEFSNGIGWRIAGGILVLLVCSINMYFVVVYVQELGHVALYVVAAVVSVAYLGFVFYLGWQCLIALGLSFLDCGRSYHLGLTARPEIYLLNTVDAVSLVSR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	KIPDDGASGDHGDSA CCCCCCCCCCCCCCC	50.73	22673903
21	Phosphorylation	ASGDHGDSASLGAIN CCCCCCCCCCCCCCC	25.09	22668510
23	Phosphorylation	GDHGDSASLGAINPA CCCCCCCCCCCCCCC	31.15	22668510
31	Phosphorylation	LGAINPAYSNSSLPH CCCCCCCCCCCCCCC	15.05	22673903
32	Phosphorylation	GAINPAYSNSSLPHS CCCCCCCCCCCCCCC	32.13	22673903
34	Phosphorylation	INPAYSNSSLPHSTG CCCCCCCCCCCCCCC	27.58	22673903
35	Phosphorylation	NPAYSNSSLPHSTGD CCCCCCCCCCCCCCC	50.61	22673903
39	Phosphorylation	SNSSLPHSTGDSEEP CCCCCCCCCCCCCCC	31.95	22673903
40	Phosphorylation	NSSLPHSTGDSEEPF CCCCCCCCCCCCCCC	41.81	22673903
43	Phosphorylation	LPHSTGDSEEPFTTY CCCCCCCCCCCCCCC	45.25	22673903
48	Phosphorylation	GDSEEPFTTYFDEKI CCCCCCCCCCCCCCC	31.16	22673903
49	Phosphorylation	DSEEPFTTYFDEKIP CCCCCCCCCCCCCCC	23.67	22673903
50	Phosphorylation	SEEPFTTYFDEKIPI CCCCCCCCCCCCCCC	13.13	22673903
336	N-linked_Glycosylation	QVVEVCRNSSSPHAD HHHHHHHCCCCCCCC	40.91	-
349	N-linked_Glycosylation	ADLFPNDNSTLAVDI CCCCCCCCCCEEEEE	43.46	-
555 (in isoform 2)	Phosphorylation	-	11.95	27097102
556 (in isoform 2)	Phosphorylation	-	3.50	27097102
560 (in isoform 2)	Phosphorylation	-	4.29	27097102
561 (in isoform 2)	Ubiquitination	-	38.93	-
564	Phosphorylation	LNTVDAVSLVSR--- EECHHHHHHHCC---	25.44	-
567	Phosphorylation	VDAVSLVSR------ HHHHHHHCC------	37.25	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NRAM2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NRAM2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NRAM2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of NRAM2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.