| UniProt ID | NPT2C_HUMAN | |
|---|---|---|
| UniProt AC | Q8N130 | |
| Protein Name | Sodium-dependent phosphate transport protein 2C | |
| Gene Name | SLC34A3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 599 | |
| Subcellular Localization |
Membrane Multi-pass membrane protein. |
|
| Protein Description | May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 20-30% of the apical influx.. | |
| Protein Sequence | MPSSLPGSQVPHPTLDAVDLVEKTLRNEGTSSSAPVLEEGDTDPWTLPQLKDTSQPWKELRVAGRLRRVAGSVLKACGLLGSLYFFICSLDVLSSAFQLLGSKVAGDIFKDNVVLSNPVAGLVIGVLVTALVQSSSTSSSIVVSMVAAKLLTVRVSVPIIMGVNVGTSITSTLVSMAQSGDRDEFQRAFSGSAVHGIFNWLTVLVLLPLESATALLERLSELALGAASLTPRAQAPDILKVLTKPLTHLIVQLDSDMIMSSATGNATNSSLIKHWCGTTGQPTQENSSCGAFGPCTEKNSTAPADRLPCRHLFAGTELTDLAVGCILLAGSLLVLCGCLVLIVKLLNSVLRGRVAQVVRTVINADFPFPLGWLGGYLAVLAGAGLTFALQSSSVFTAAVVPLMGVGVISLDRAYPLLLGSNIGTTTTALLAALASPADRMLSALQVALIHFFFNLAGILLWYLVPALRLPIPLARHFGVVTARYRWVAGVYLLLGFLLLPLAAFGLSLAGGMELAAVGGPLVGLVLLVILVTVLQRRRPAWLPVRLRSWAWLPVWLHSLEPWDRLVTRCCPCNVCSPPKATTKEAYCYENPEILASQQL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MPSSLPGSQV -----CCCCCCCCCC | 43.11 | 28857561 | |
| 4 | Phosphorylation | ----MPSSLPGSQVP ----CCCCCCCCCCC | 32.48 | 28857561 | |
| 8 | Phosphorylation | MPSSLPGSQVPHPTL CCCCCCCCCCCCCCC | 26.51 | 21964256 | |
| 33 | Phosphorylation | RNEGTSSSAPVLEEG HCCCCCCCCCCCCCC | 36.04 | 28857561 | |
| 72 | Phosphorylation | RLRRVAGSVLKACGL HHHHHHHHHHHHHHH | 17.97 | 29523821 | |
| 84 | Phosphorylation | CGLLGSLYFFICSLD HHHHHHHHHHHHHHH | 9.72 | - | |
| 135 | Phosphorylation | VTALVQSSSTSSSIV HHHHHHCCCCCCHHH | 22.12 | - | |
| 220 | Phosphorylation | TALLERLSELALGAA HHHHHHHHHHHHHHH | 36.46 | - | |
| 228 | Phosphorylation | ELALGAASLTPRAQA HHHHHHHCCCCHHHC | 32.04 | - | |
| 265 | N-linked_Glycosylation | IMSSATGNATNSSLI CHHHCCCCCCCHHHH | 38.96 | UniProtKB CARBOHYD | |
| 268 | N-linked_Glycosylation | SATGNATNSSLIKHW HCCCCCCCHHHHHHH | 27.47 | UniProtKB CARBOHYD | |
| 270 | Phosphorylation | TGNATNSSLIKHWCG CCCCCCHHHHHHHCC | 35.86 | 24719451 | |
| 286 | N-linked_Glycosylation | TGQPTQENSSCGAFG CCCCCCCCCCCCCCC | 29.43 | UniProtKB CARBOHYD | |
| 299 | N-linked_Glycosylation | FGPCTEKNSTAPADR CCCCCCCCCCCCCCC | 38.06 | UniProtKB CARBOHYD | |
| 435 | Phosphorylation | ALLAALASPADRMLS HHHHHHCCHHHHHHH | 22.82 | - | |
| 481 | Phosphorylation | ARHFGVVTARYRWVA HHHHCCCHHHHHHHH | 11.74 | - | |
| 576 | Phosphorylation | CCPCNVCSPPKATTK HCCCCCCCCCCCCCC | 39.70 | - | |
| 581 | Phosphorylation | VCSPPKATTKEAYCY CCCCCCCCCCCEECC | 44.52 | - | |
| 582 | Phosphorylation | CSPPKATTKEAYCYE CCCCCCCCCCEECCC | 31.57 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NPT2C_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NPT2C_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NPT2C_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of NPT2C_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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