NPT2A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NPT2A_HUMAN
• UniProt AC: Q06495
• Protein Name: Sodium-dependent phosphate transport protein 2A
• Gene Name: SLC34A1 {ECO:0000312|HGNC:HGNC:11019}
• Organism: Homo sapiens (Human).
• Sequence Length: 639
• Subcellular Localization: Apical cell membrane ; Multi-pass membrane protein .
• Protein Description: Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx..
• Protein Sequence: MLSYGERLGSPAVSPLPVRGGHVMRGTAFAYVPSPQVLHRIPGTSAYAFPSLGPVALAEHTCPCGEVLERHEPLPAKLALEEEQKPESRLVPKLRQAGAMLLKVPLMLTFLYLFVCSLDMLSSAFQLAGGKVAGDIFKDNAILSNPVAGLVVGILVTVLVQSSSTSTSIIVSMVSSGLLEVSSAIPIIMGSNIGTSVTNTIVALMQAGDRTDFRRAFAGATVHDCFNWLSVLVLLPLEAATGYLHHITRLVVASFNIHGGRDAPDLLKIITEPFTKLIIQLDESVITSIATGDESLRNHSLIQIWCHPDSLQAPTSMSRAEANSSQTLGNATMEKCNHIFVDTGLPDLAVGLILLAGSLVLLCTCLILLVKMLNSLLKGQVAKVIQKVINTDFPAPFTWVTGYFAMVVGASMTFVVQSSSVFTSAITPLIGLGVISIERAYPLTLGSNIGTTTTAILAALASPREKLSSAFQIALCHFFFNISGILLWYPVPCTRLPIRMAKALGKRTAKYRWFAVLYLLVCFLLLPSLVFGISMAGWQVMVGVGTPFGALLAFVVLINVLQSRSPGHLPKWLQTWDFLPRWMHSLKPLDHLITRATLCCARPEPRSPPLPPRVFLEELPPATPSPRLALPAHHNATRL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MLSYGERLGS -----CCCCHHCCCC	29.78	24043423
4	Phosphorylation	----MLSYGERLGSP ----CCCCHHCCCCC	21.03	24043423
10	Phosphorylation	SYGERLGSPAVSPLP CCHHCCCCCCCCCCC	17.80	28857561
14	Phosphorylation	RLGSPAVSPLPVRGG CCCCCCCCCCCCCCC	23.87	28857561
34	Phosphorylation	TAFAYVPSPQVLHRI CEEEEECCCHHHCCC	20.23	28857561
288	Phosphorylation	LDESVITSIATGDES CCHHHHHHHHCCCHH	10.09	-
298	N-linked_Glycosylation	TGDESLRNHSLIQIW CCCHHHHCCCEEEEE	34.10	UniProtKB CARBOHYD
321 (in isoform 2)	Phosphorylation	-	47.47	25690035
323	N-linked_Glycosylation	SMSRAEANSSQTLGN CCCHHHHHCCCHHCC	33.43	UniProtKB CARBOHYD
330	N-linked_Glycosylation	NSSQTLGNATMEKCN HCCCHHCCHHHHHCC	35.04	UniProtKB CARBOHYD
375	Phosphorylation	LLVKMLNSLLKGQVA HHHHHHHHHHHHHHH	30.99	24719451
508	Phosphorylation	AKALGKRTAKYRWFA HHHHCCCCHHHHHHH	30.87	-
607	Phosphorylation	CARPEPRSPPLPPRV HCCCCCCCCCCCCCC	41.40	-
623	Phosphorylation	LEELPPATPSPRLAL HHHCCCCCCCCCCCC	30.03	-
625	Phosphorylation	ELPPATPSPRLALPA HCCCCCCCCCCCCCC	20.49	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
508	T	Phosphorylation	Kinase	PKC	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NPT2A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NPT2A_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of NPT2A_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.