NOVA2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NOVA2_HUMAN
• UniProt AC: Q9UNW9
• Protein Name: RNA-binding protein Nova-2
• Gene Name: NOVA2
• Organism: Homo sapiens (Human).
• Sequence Length: 492
• Subcellular Localization: Nucleus.
• Protein Description: May regulate RNA splicing or metabolism in a specific subset of developing neurons (By similarity). Binds single strand RNA..
• Protein Sequence: MEPEAPDSRKRPLETPPEVVCTKRSNTGEEGEYFLKVLIPSYAAGSIIGKGGQTIVQLQKETGATIKLSKSKDFYPGTTERVCLVQGTAEALNAVHSFIAEKVREIPQAMTKPEVVNILQPQTTMNPDRAKQAKLIVPNSTAGLIIGKGGATVKAVMEQSGAWVQLSQKPEGINLQERVVTVSGEPEQVHKAVSAIVQKVQEDPQSSSCLNISYANVAGPVANSNPTGSPYASPADVLPAAAAASAAAASGLLGPAGLAGVGAFPAALPAFSGTDLLAISTALNTLASYGYNTNSLGLGLNSAAASGVLAAVAAGANPAAAAAANLLASYAGEAGAGPAGGAAPPPPPPPGALGSFALAAAANGYLGAGAGGGAGGGGGPLVAAAAAAGAAGGFLTAEKLAAESAKELVEIAVPENLVGAILGKGGKTLVEYQELTGARIQISKKGEFLPGTRNRRVTITGSPAATQAAQYLISQRVTYEQGVRASNPQKVG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	SRKRPLETPPEVVCT CCCCCCCCCCCEEEE	52.40	30266825
25	Phosphorylation	EVVCTKRSNTGEEGE CEEEECCCCCCCCCE	40.06	28857561
27	Phosphorylation	VCTKRSNTGEEGEYF EEECCCCCCCCCEEE	47.41	28857561
41	Phosphorylation	FLKVLIPSYAAGSII EEEHHCHHHCCCCCC	22.02	-
42	Phosphorylation	LKVLIPSYAAGSIIG EEHHCHHHCCCCCCC	8.63	-
50	Ubiquitination	AAGSIIGKGGQTIVQ CCCCCCCCCCCEEEE	49.84	30230243
67	Ubiquitination	KETGATIKLSKSKDF HHHCCEEEEECCCCC	42.21	32142685
112	Sumoylation	EIPQAMTKPEVVNIL HCCHHHCCHHHHCCC	26.54	28112733
152	Phosphorylation	IIGKGGATVKAVMEQ EECCCCHHHHHHHHH	26.30	22210691
160	Phosphorylation	VKAVMEQSGAWVQLS HHHHHHHCCCEEEEC	19.71	22210691
167	Phosphorylation	SGAWVQLSQKPEGIN CCCEEEECCCCCCCC	21.04	22210691
194	Phosphorylation	EQVHKAVSAIVQKVQ HHHHHHHHHHHHHHH	19.69	-
427	Ubiquitination	AILGKGGKTLVEYQE HHHCCCCCEEEEEEE	47.56	30230243
445	Ubiquitination	ARIQISKKGEFLPGT CEEEEECCCCCCCCC	57.81	32142685
458	Phosphorylation	GTRNRRVTITGSPAA CCCCCEEEEECCHHH	15.83	27732954
460	Phosphorylation	RNRRVTITGSPAATQ CCCEEEEECCHHHHH	23.42	27732954
462	Phosphorylation	RRVTITGSPAATQAA CEEEEECCHHHHHHH	11.60	27732954
466	Phosphorylation	ITGSPAATQAAQYLI EECCHHHHHHHHHHH	22.35	27732954
474	Phosphorylation	QAAQYLISQRVTYEQ HHHHHHHHCCCHHHC	14.89	24719451
478	Phosphorylation	YLISQRVTYEQGVRA HHHHCCCHHHCCCCC	24.43	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
25	S	Phosphorylation	Kinase	CAMK4	Q16566	PSP
27	T	Phosphorylation	Kinase	CAMK4	Q16566	PSP
194	S	Phosphorylation	Kinase	CAMK4	Q16566	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NOVA2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NOVA2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of NOVA2_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.