NOSTN_HUMAN - dbPTM
NOSTN_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NOSTN_HUMAN
UniProt AC Q8IVI9
Protein Name Nostrin
Gene Name NOSTRIN
Organism Homo sapiens (Human).
Sequence Length 506
Subcellular Localization Isoform 1: Cell membrane
Peripheral membrane protein
Cytoplasmic side . Cytoplasmic vesicle . Cytoplasm, cytoskeleton . Enriched in selected actin structures (PubMed:16234328, PubMed:16376344).
Isoform 3: Nucleus .
Protein Description Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane..
Protein Sequence MRDPLTDCPYNKVYKNLKEFSQNGENFCKQVTSVLQQRANLEISYAKGLQKLASKLSKALQNTRKSCVSSAWAWASEGMKSTADLHQKLGKAIELEAIKPTYQVLNVQEKKRKSLDNEVEKTANLVISNWNQQIKAKKKLMVSTKKHEALFQLVESSKQSMTEKEKRKLLNKLTKSTEKLEKEDENYYQKNMAGYSTRLKWENTLENCYQSILELEKERIQLLCNNLNQYSQHISLFGQTLTTCHTQIHCAISKIDIEKDIQAVMEETAILSTENKSEFLLTDYFEEDPNSAMDKERRKSLLKPKLLRLQRDIEKASKDKEGLERMLKTYSSTSSFSDAKSQKDTAALMDENNLKLDLLEANSYKLSSMLAELEQRPQPSHPCSNSIFRWREKEHTHSYVKISRPFLMKRLENIVSKASSGGQSNPGSSTPAPGAAQLSSRLCKALYSFQARQDDELNLEKGDIVIIHEKKEGGWWFGSLNGKKGHFPAAYVEELPSNAGNTATKA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
44PhosphorylationQRANLEISYAKGLQK
HHHCCCHHHHHHHHH		15.0623403867
60UbiquitinationASKLSKALQNTRKSC
HHHHHHHHHHHHHHH		4.6633845483
88UbiquitinationSTADLHQKLGKAIEL
CHHHHHHHHHHHHHH		48.7533845483
113"N6,N6-dimethyllysine"NVQEKKRKSLDNEVE
CHHHHHHHCCCCHHH		65.34-
113MethylationNVQEKKRKSLDNEVE
CHHHHHHHCCCCHHH		65.3423644510
114PhosphorylationVQEKKRKSLDNEVEK
HHHHHHHCCCCHHHH		45.0126657352
143PhosphorylationAKKKLMVSTKKHEAL
HHHCCEECCHHHHHH		22.12-
144PhosphorylationKKKLMVSTKKHEALF
HHCCEECCHHHHHHH		32.47-
174PhosphorylationRKLLNKLTKSTEKLE
HHHHHHHHHCHHHHH		25.2622817900
176PhosphorylationLLNKLTKSTEKLEKE
HHHHHHHCHHHHHHH		36.2422817900
177PhosphorylationLNKLTKSTEKLEKED
HHHHHHCHHHHHHHH		38.4022817900
231 (in isoform 4)Phosphorylation-12.91-
277PhosphorylationILSTENKSEFLLTDY
EEECCCCHHEECCHH		45.2028450419
300PhosphorylationMDKERRKSLLKPKLL
CCHHHHHHHHHHHHH		36.8024719451
329PhosphorylationGLERMLKTYSSTSSF
HHHHHHHHHHCCCCH		25.3630177828
330PhosphorylationLERMLKTYSSTSSFS
HHHHHHHHHCCCCHH		10.0723312004
331PhosphorylationERMLKTYSSTSSFSD
HHHHHHHHCCCCHHH		32.1628857561
332PhosphorylationRMLKTYSSTSSFSDA
HHHHHHHCCCCHHHH		23.1528857561
333PhosphorylationMLKTYSSTSSFSDAK
HHHHHHCCCCHHHHH		23.5828857561
334PhosphorylationLKTYSSTSSFSDAKS
HHHHHCCCCHHHHHC		31.1926434776
335PhosphorylationKTYSSTSSFSDAKSQ
HHHHCCCCHHHHHCH		28.9428857561
337PhosphorylationYSSTSSFSDAKSQKD
HHCCCCHHHHHCHHH		38.3126434776
386PhosphorylationPSHPCSNSIFRWREK
CCCCCCCCCEEEHHH		13.5528857561
396PhosphorylationRWREKEHTHSYVKIS
EEHHHCCCCCCEEEC		17.3829449344
398PhosphorylationREKEHTHSYVKISRP
HHHCCCCCCEEECHH		32.5429449344
399PhosphorylationEKEHTHSYVKISRPF
HHCCCCCCEEECHHH		9.7329449344
403PhosphorylationTHSYVKISRPFLMKR
CCCCEEECHHHHHHH		28.3429449344
419PhosphorylationENIVSKASSGGQSNP
HHHHHHHHCCCCCCC		33.0023312004
420PhosphorylationNIVSKASSGGQSNPG
HHHHHHHCCCCCCCC		52.3723312004
424PhosphorylationKASSGGQSNPGSSTP
HHHCCCCCCCCCCCC		48.5525262027
428PhosphorylationGGQSNPGSSTPAPGA
CCCCCCCCCCCCCCH		32.0923312004
429PhosphorylationGQSNPGSSTPAPGAA
CCCCCCCCCCCCCHH		44.3023312004
430PhosphorylationQSNPGSSTPAPGAAQ
CCCCCCCCCCCCHHH		25.7623312004
447PhosphorylationSRLCKALYSFQARQD
HHHHHHHHHHHCCCC		16.5827259358
448PhosphorylationRLCKALYSFQARQDD
HHHHHHHHHHCCCCC		16.2528857561
479PhosphorylationEGGWWFGSLNGKKGH
CCCEEEECCCCCCCC		14.80-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NOSTN_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NOSTN_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NOSTN_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NOS3_HUMANNOS3physical
12446846
KDM1A_HUMANKDM1Aphysical
23455924
ANM6_HUMANPRMT6physical
23455924
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NOSTN_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry.";
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-174; SER-176 ANDTHR-177, AND MASS SPECTROMETRY.

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