dbPTM

NOP58_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NOP58_SCHPO
UniProt AC	Q9P7S7
Protein Name	Nucleolar protein 58
Gene Name	nop58
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	508
Subcellular Localization	Nucleus, nucleolus .
Protein Description	Required for pre-18S rRNA processing. May bind microtubules (By similarity)..
Protein Sequence	MFILTETAAGYAIFKAKDKLLKKRDALIEDLKSPEGASNLLKLQSFAKFESTVDALDNVSALVEGKVSSKLSSLLEGLSDSKSSTLVVADPKLGNAINKLPGLEFEIISDSSVQDLYRGIREHLSSLISGLAPSDLNAMSLGLSHSLSRHKLKFSPDKVDTMIVQAIALLDDLDKELNTYAMRVREWYGWHFPEMGKIIQDNLAYARVIKAMGMRTKCSETDFSDILPEEIEATLKSAAEISMGTEITEEDLDNIVMLADQVLELASYRAQLSEYLRNRMQAIAPNLTALVGELVGARLIAHAGSLMNLAKQPASTIQILGAEKALFRALKTKHSTPKYGLIYHASLVGQANSKNKGKIARVLATKAALSLRVDALSDKDTTNGNIGLENRIRVENRLRSLEGGKLLPLPTAPVQQSKVQINGTSAYSTATDAVTKDAEESQEDVEMDIVIEKKKKKSSKLKEADGESSKKEKKEKKDKKHKKSKRKSEESEDGESPKKKKKSKKSKD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Phosphorylation	ALIEDLKSPEGASNL HHHHHHCCCCHHHHH	35.17	28889911
38	Phosphorylation	LKSPEGASNLLKLQS HCCCCHHHHHHHHHH	38.58	21712547
68	Phosphorylation	ALVEGKVSSKLSSLL HHHCCHHHHHHHHHH	25.82	25720772
377	Phosphorylation	SLRVDALSDKDTTNG HHHHHHCCCCCCCCC	44.31	25720772
381	Phosphorylation	DALSDKDTTNGNIGL HHCCCCCCCCCCCCH	28.09	25720772
411	Phosphorylation	GKLLPLPTAPVQQSK CEEECCCCCCCCCCE	51.80	25720772
441	Phosphorylation	VTKDAEESQEDVEMD HCCCHHHHHHHHCHH	30.30	28889911
488	Phosphorylation	HKKSKRKSEESEDGE HHHHHHHHHCCCCCC	51.10	21712547
491	Phosphorylation	SKRKSEESEDGESPK HHHHHHCCCCCCCCC	36.62	24763107
496	Phosphorylation	EESEDGESPKKKKKS HCCCCCCCCCHHCCC	47.77	21712547

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NOP58_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NOP58_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NOP58_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of NOP58_SCHPO !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NOP58_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-33 AND SER-441, AND MASSSPECTROMETRY.	18257517 [Abstract]