dbPTM

NOP2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NOP2_SCHPO
UniProt AC	O94268
Protein Name	25S rRNA (cytosine-C(5))-methyltransferase nop2
Gene Name	nop2
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	608
Subcellular Localization	Nucleus . Nucleus, nucleolus.
Protein Description	S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of a cytosine in 25S rRNA. Required for 60S ribosomal subunit synthesis and processing (By similarity)..
Protein Sequence	MGRKQKSKQGIPPTLEENHNSSHKVTENAKKRKHSKEKPQNSRKRQLAEEKKSLFENSDSENEKDLIDADEFEEAETLSDLEHDEEPQTFADEFIDDEAKECEGEEEDSVFDSDEEHEVKPMFSDDSGDEEDLELANMEAMSRKLDEEAELEEKEAEEELHTNIHPEAPTVLPPIDGFTDSQPISTLPQDLSQIQLRIQEIVRVLNDFKNLCEPGRNRSEYVDQLLNDICAYYGYSRFLAEKLFELFSVSEAVEFFEANEMPRPVTIRTNTLKTQRRELAQALINRGVNLEPIGKWSKVGLQVFESQVPIGATPEYLAGHYILQAASSFLPVMALAPQPNERILDMSSAPGGKVTYVAALQKNTGIIFANDSNKARTKALSANIHRLGVRNAIVCNYDGRKFPNEVIGGFDRVLLDAPCSGTGVIYKDQSVKTNKSERDFDTLSHLQRQLLLSAIDSVNADSKTGGFIVYSTCSITVDEDEAVIQYALKKRPNVKLVSTGLEFGREGFTRFREKRFHPSLKLTRRYYPHVHNIDGFFVAKLKKISDKIPTVNVADDMKDGTNNDVEIEKNSTEIDNITFNDEADKEIIEQNRRKWLKSKGYKVAKKKD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
58	Phosphorylation	KKSLFENSDSENEKD HHHHHCCCCCCCHHH	35.00	28889911
60	Phosphorylation	SLFENSDSENEKDLI HHHCCCCCCCHHHCC	41.99	28889911
77	Phosphorylation	DEFEEAETLSDLEHD HHHHHHHCHHCCCCC	38.31	21712547
79	Phosphorylation	FEEAETLSDLEHDEE HHHHHCHHCCCCCCC	47.79	21712547
89	Phosphorylation	EHDEEPQTFADEFID CCCCCCCCHHHHHCC	31.35	29996109
124	Phosphorylation	HEVKPMFSDDSGDEE CCCCCCCCCCCCCHH	33.97	21712547
127	Phosphorylation	KPMFSDDSGDEEDLE CCCCCCCCCCHHHHH	53.81	21712547

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NOP2_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NOP2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NOP2_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of NOP2_SCHPO !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NOP2_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-58 AND SER-60, AND MASSSPECTROMETRY.	18257517 [Abstract]