dbPTM

NOP12_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NOP12_SCHPO
UniProt AC	O13741
Protein Name	Nucleolar protein 12
Gene Name	nop12
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	438
Subcellular Localization	Nucleus, nucleolus.
Protein Description	Involved in pre-25S rRNA processing..
Protein Sequence	MGETNSSLDNENTSFVGKLSSSSNVDPTLNLLFSQSKPIPKPVAKETTVLTKKDVEVEEANGVEEAAETIESDTKEVQNIKPKSKKKKKKLNDSSDDIEGKYFEELLAEEDEEKDKDSAGLINDEEDKSPAKQSVLEERTSQEDVKSEREVAEKLANELEKSDKTVFVNNLPARVVTNKGDYKDLTKHFRQFGAVDSIRFRSLAFSEAIPRKVAFFEKKFHSERDTVNAYIVFRDSSSARSALSLNGTMFMDRHLRVDSVSHPMPQDTKRCVFVGNLAFEAEEEPLWRYFGDCGSIDYVRIVRDPKTNLGKGFAYIQFKDTMGVDKALLLNEKKMPEGRTLRIMRAKSTKPKSITRSKRGDEKTRTLQGRARKLIGKAGNALLQQELALEGHRAKPGENPLAKKKVNKKRKERAAQWRNKKAESVGKKQKTAAGKKDK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MGETNSSLDNE ----CCCCCCCCCCC	34.37	29996109
6	Phosphorylation	--MGETNSSLDNENT --CCCCCCCCCCCCC	39.43	21712547
7	Phosphorylation	-MGETNSSLDNENTS -CCCCCCCCCCCCCC	41.64	24763107
13	Phosphorylation	SSLDNENTSFVGKLS CCCCCCCCCCCEECC	19.84	29996109
14	Phosphorylation	SLDNENTSFVGKLSS CCCCCCCCCCEECCC	29.53	21712547
72	Phosphorylation	EAAETIESDTKEVQN HHHHHHHHCCHHHHC	46.89	24763107
74	Phosphorylation	AETIESDTKEVQNIK HHHHHHCCHHHHCCC	38.08	21712547
94	Phosphorylation	KKKKLNDSSDDIEGK CHHHCCCCCCCCCHH	34.29	28889911
95	Phosphorylation	KKKLNDSSDDIEGKY HHHCCCCCCCCCHHH	42.01	28889911
129	Phosphorylation	INDEEDKSPAKQSVL CCCCCCCCHHHHHHH	42.27	24763107
134	Phosphorylation	DKSPAKQSVLEERTS CCCHHHHHHHHHHCC	28.15	21712547
140	Phosphorylation	QSVLEERTSQEDVKS HHHHHHHCCHHHHHH	37.73	24763107
141	Phosphorylation	SVLEERTSQEDVKSE HHHHHHCCHHHHHHH	37.48	21712547
147	Phosphorylation	TSQEDVKSEREVAEK CCHHHHHHHHHHHHH	41.56	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NOP12_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NOP12_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NOP12_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of NOP12_SCHPO !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NOP12_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94 AND SER-95, AND MASSSPECTROMETRY.	18257517 [Abstract]