NOB1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NOB1_SCHPO
• UniProt AC: Q9UTK0
• Protein Name: 20S-pre-rRNA D-site endonuclease nob1
• Gene Name: nob1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 388
• Subcellular Localization: Cytoplasm. Nucleus, nucleolus.
• Protein Description: Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm (By similarity)..
• Protein Sequence: MSKSITHLVLDTGGIICSSTLLRNSAESFYTIPRVIAEIRDETSRKNFELWGDQVIQRVPKPEFIKKVSEFAKQTGDYSSLSVTDIQILALTYELEVEFNGGDWRLRKYPGQKHINGKPPSNSNSTEDASKPTSSDTASVKETENSDPKSAENEVLEGETTQHSNNKEAHPNTEENKEQEDNEEDDEDDGWITPSNIRKKKAEDGVGESLVQPKHLKVACATTDFSMQNVLLQIGLNLVSSDGFKIQNVKRFVLRCHGCYTVVKDMEKKFCPSCGGNTLIKTTCSINSKGEFQVHLKKNFEWKTRGTKYSLPKPVHGTSNGKGKKNPVLREDQPEYQRAVRRMQRKKEIDLMDEDYLPSLLTGVTKDRMYVQIGAGRKNPNEVRRKKR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
123	Phosphorylation	NGKPPSNSNSTEDAS CCCCCCCCCCCCCCC	36.17	24763107
125	Phosphorylation	KPPSNSNSTEDASKP CCCCCCCCCCCCCCC	32.75	24763107
126	Phosphorylation	PPSNSNSTEDASKPT CCCCCCCCCCCCCCC	41.98	24763107
133	Phosphorylation	TEDASKPTSSDTASV CCCCCCCCCCCCCCC	44.60	21712547
134	Phosphorylation	EDASKPTSSDTASVK CCCCCCCCCCCCCCE	34.44	21712547
137	Phosphorylation	SKPTSSDTASVKETE CCCCCCCCCCCEECC	23.84	21712547
139	Phosphorylation	PTSSDTASVKETENS CCCCCCCCCEECCCC	35.50	24763107
150	Phosphorylation	TENSDPKSAENEVLE CCCCCCCCHHHHHHC	46.32	24763107
193	Phosphorylation	DEDDGWITPSNIRKK CCCCCCCCHHHHCCC	17.73	24763107

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NOB1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NOB1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NOB1_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of NOB1_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.