NMT1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NMT1_MOUSE
• UniProt AC: O70310
• Protein Name: Glycylpeptide N-tetradecanoyltransferase 1
• Gene Name: Nmt1
• Organism: Mus musculus (Mouse).
• Sequence Length: 496
• Subcellular Localization: Cytoplasm . Cytoplasm, cytosol . Membrane ; Peripheral membrane protein . Copurifies with ribosomes.
• Protein Description: Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. Required for normal embryogenesis..
• Protein Sequence: MADESETAVKLPAPSLPLMMEGNGNGHEHCSDCENEEDNSHNRSGLSPANDTGAKKKKKKQKKKKEKGSDMESTQDQPVKMTSLPAERIQEIQKAIELFSVGQGPAKTMEEASKRSYQFWDTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLPQGFTWDALDLGDRGVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEKKMVEINFLCVHKKLRSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRSLNPRKLIEVKFSHLSRNMTMQRTMKLYRLPETPKTAGLRPMEKKDIPVVHQLLSRYLKQFHLTPVMNQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTLPSTIMNHPTHKSLKAAYSFYNVHTQTPLLDLMSDALVLAKMKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWKCPSMGAEKVGLVLQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MADESETAVKLP ---CCCHHCCCEECC	40.57	25367039
7	Phosphorylation	-MADESETAVKLPAP -CCCHHCCCEECCCC	46.13	25367039
15	Phosphorylation	AVKLPAPSLPLMMEG CEECCCCCCCEEECC	44.73	28285833
19	Oxidation	PAPSLPLMMEGNGNG CCCCCCEEECCCCCC	1.86	17242355
31	Phosphorylation	GNGHEHCSDCENEED CCCCCCCCCCCCCCC	47.40	25521595
40	Phosphorylation	CENEEDNSHNRSGLS CCCCCCCCCCCCCCC	34.17	23140645
44	Phosphorylation	EDNSHNRSGLSPAND CCCCCCCCCCCCCCC	49.78	27087446
47	Phosphorylation	SHNRSGLSPANDTGA CCCCCCCCCCCCHHH	26.03	27087446
52	Phosphorylation	GLSPANDTGAKKKKK CCCCCCCHHHHHHHH	38.56	28833060
55	Acetylation	PANDTGAKKKKKKQK CCCCHHHHHHHHHHH	67.48	129121
69	Phosphorylation	KKKKEKGSDMESTQD HHHHHCCCCCCCCCC	44.87	27087446
73	Phosphorylation	EKGSDMESTQDQPVK HCCCCCCCCCCCCCC	25.40	25521595
74	Phosphorylation	KGSDMESTQDQPVKM CCCCCCCCCCCCCCC	23.90	25777480
80	Ubiquitination	STQDQPVKMTSLPAE CCCCCCCCCCCCCHH	43.05	22790023
82	Phosphorylation	QDQPVKMTSLPAERI CCCCCCCCCCCHHHH	22.76	28066266
83	Phosphorylation	DQPVKMTSLPAERIQ CCCCCCCCCCHHHHH	28.93	24453211
94	Ubiquitination	ERIQEIQKAIELFSV HHHHHHHHHHHHHCC	57.92	22790023
100	Phosphorylation	QKAIELFSVGQGPAK HHHHHHHCCCCCCCC	37.65	29514104
107	Ubiquitination	SVGQGPAKTMEEASK CCCCCCCCCHHHHHH	52.09	22790023
300	Phosphorylation	TCRYWHRSLNPRKLI CCCHHHHCCCHHHEE	21.44	22871156
305	Acetylation	HRSLNPRKLIEVKFS HHCCCHHHEEEEECH	55.89	22826441
310	Ubiquitination	PRKLIEVKFSHLSRN HHHEEEEECHHHCCC	28.49	22790023
310	Acetylation	PRKLIEVKFSHLSRN HHHEEEEECHHHCCC	28.49	22826441
323	Phosphorylation	RNMTMQRTMKLYRLP CCCCHHHHHHHHCCC	11.19	18779572
332	Phosphorylation	KLYRLPETPKTAGLR HHHCCCCCCCCCCCC	28.31	29514104
354	Phosphorylation	PVVHQLLSRYLKQFH HHHHHHHHHHHHHCC	27.72	24719451
356	Phosphorylation	VHQLLSRYLKQFHLT HHHHHHHHHHHCCCC	18.18	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NMT1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NMT1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NMT1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NMT1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, AND MASSSPECTROMETRY.
PubMed: 17242355