NMDE3_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NMDE3_RAT
• UniProt AC: Q00961
• Protein Name: Glutamate receptor ionotropic, NMDA 2C
• Gene Name: Grin2c
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1237
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein .
• Protein Description: Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). [PubMed: 1350383]
• Protein Sequence: MGGALGPALLLTSLLGAWARLGAGQGEQAVTVAVVFGSSGPLQTQARTRLTSQNFLDLPLEIQPLTVGVNNTNPSSILTQICGLLGAARVHGIVFEDNVDTEAVAQLLDFVSSQTHVPILSISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLEGVRAVADASYLSWRLLDVLTLELGPGGPRARTQRLLRQVDAPVLVAYCSREEAEVLFAEAAQAGLVGPGHVWLVPNLALGSTDAPPAAFPVGLISVVTESWRLSLRQKVRDGVAILALGAHSYRRQYGTLPAPAGDCRSHPGPVSPAREAFYRHLLNVTWEGRDFSFSPGGYLVRPTMVVIALNRHRLWEMVGRWDHGVLYMKYPVWPRYSTSLQPVVDSRHLTVATLEERPFVIVESPDPGTGGCVPNTVPCRRQSNHTFSSGDLTPYTKLCCKGFCIDILKKLAKVVKFSYDLYLVTNGKHGKRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIIDFSVPFVETGISVMVSRSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTKGKKPGGPSFTIGKSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQRSVEDALTSLKMGKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQLLGDGETQKLETVWLSGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVYWKLRHSVPNSSQLDFLLAFSRGIYSCFNGVQSLPSPARPPSPDLTADSAQANVLKMLQAARDMVNTADVSSSLDRATRTIENWGNNRRVPAPTASGPRSSTPGPPGQPSPSGWGPPGGGRTPLARRAPQPPARPATCGPPLPDVSRPSCRHASDARWPVRVGHQGPHVSASERRALPERSLLPAHCHYSSFPRAERSGRPYLPLFPEPPEPDDLPLLGPEQLARREAMLRAAWARGPRPRHASLPSSVAEAFTRSNPLPARCTGHACACPCPQSRPSCRHLAQAQSLRLPSYPEACVEGVPAGVATWQPRQHVCLHAHTRLPFCWGTVCRHPPPCTSHSPWLIGTWEPPAHRVRTLGLGTGYRDSGVLEEVSREACGTQGFPRSCTWRRVSSLESEV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
70	N-linked_Glycosylation	QPLTVGVNNTNPSSI EEEEEECCCCCHHHH	43.62	-
73	N-linked_Glycosylation	TVGVNNTNPSSILTQ EEECCCCCHHHHHHH	36.26	-
337	N-linked_Glycosylation	AFYRHLLNVTWEGRD HHHHHHHCCEECCCC	35.22	-
438	N-linked_Glycosylation	VPCRRQSNHTFSSGD CCCCCCCCCCCCCCC	29.85	-
539	N-linked_Glycosylation	SVMVSRSNGTVSPSA EEEEECCCCCCCHHH	49.39	-
591	Acetylation	QNLTKGKKPGGPSFT CCCCCCCCCCCCCCC	58.52	22902405
685	N-linked_Glycosylation	FRFGTVPNGSTERNI CCCCCCCCCCCCCCH	53.35	-
875	Phosphorylation	NGVQSLPSPARPPSP CCHHHCCCCCCCCCC	36.16	-
881	Phosphorylation	PSPARPPSPDLTADS CCCCCCCCCCCCCCH	33.46	-
910	Phosphorylation	MVNTADVSSSLDRAT HCHHCCHHHHHHHHH	18.11	22673903
911	Phosphorylation	VNTADVSSSLDRATR CHHCCHHHHHHHHHH	34.47	22673903
912	Phosphorylation	NTADVSSSLDRATRT HHCCHHHHHHHHHHH	27.12	28126851
1083	Phosphorylation	GPRPRHASLPSSVAE CCCCCCCCCCHHHHH	34.39	19477150
1231	Phosphorylation	SCTWRRVSSLESEV- CCCEEEHHHCCCCC-	27.65	16606616
1232	Phosphorylation	CTWRRVSSLESEV-- CCEEEHHHCCCCC--	33.04	22673903
1235	Phosphorylation	RRVSSLESEV----- EEHHHCCCCC-----	49.29	22673903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1083	S	Phosphorylation	Kinase	AKT1	P31749	PSP
1231	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
1231	S	Phosphorylation	Kinase	PRKCA	P17252	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NMDE3_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NMDE3_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of NMDE3_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.