NMD3A_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NMD3A_RAT
• UniProt AC: Q9R1M7
• Protein Name: Glutamate receptor ionotropic, NMDA 3A
• Gene Name: Grin3a
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1135
• Subcellular Localization: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Enriched in postsynaptic plasma membrane and postsynaptic densities. Requires th
• Protein Description: NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in the development of dendritic spines. May also play a role in PPP2CB-NMDAR mediated signaling mechanism..
• Protein Sequence: MRRLSLWWLLSRVCLLLPPPCALVLAGVPSSSSHPQPCQILKRIGHAVRVGAVHLQPWTTAPRAASRAQEGGRAGAQRDDPESGTWRPPAPSQGARWLGSALHGRGPPGSRKLGEGAGAETLWPRDALLFAVENLNRVEGLLPYNLSLEVVMAIEAGLGDLPLMPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMMELDLVSSVLHIPVLSIVRHEFPRESQNPLHLQLSLENSLSSDADVTVSILTMNNWYNFSLLLCQEDWNITDFLLLTENNSKFHLESVINITANLSSTKDLLSFLQVQMDNIRNSTPTMVMFGCDMDSIRQIFEMSTQFGLSPPELHWVLGDSQNVEELRTEGLPLGLIAHGKTTQSVFEYYVQDAMELVARAVATATMIQPELALLPSTMNCMDVKTTNLTSGQYLSRFLANTTFRGLSGSIKVKGSTIISSENNFFIWNLQHDPMGKPMWTRLGSWQGGRIVMDSGIWPEQAQRHKTHFQHPNKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSMLDRLFSSLHSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLSGTANMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAIFLTLYEWKSPFGMTPKGRNRNKVFSFSSALNVCYALLFGRTAAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVQYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTSNISELISQYKSHGFMDVLHDKWYKVVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVHRLLLPRIKNKSKLQYWLHTSQRFHRALNTSFVEEKQPRSKTKRVEKSRWRRWTCKTEGDSELSLFPRSNLGPQQLMVWNTSNLSHDNQRKYIFNDEEGQNQLGTQAHQDIPLPQRRRELPASLTTNGKADSLNVTRSSVIQELSELEKQIQVIRQELQLAVSRKTELEEYQKTNRTCES

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	LSLWWLLSRVCLLLP HHHHHHHHHHHHHCC	22.09	22673903
145	N-linked_Glycosylation	VEGLLPYNLSLEVVM CCCCCCCCCCHHHHH	22.63	-
264	N-linked_Glycosylation	LTMNNWYNFSLLLCQ EECCCCCCEEEEEEC	16.20	-
275	N-linked_Glycosylation	LLCQEDWNITDFLLL EEECCCCCCCCEEEE	39.34	-
285	N-linked_Glycosylation	DFLLLTENNSKFHLE CEEEEECCCCCEEEE	53.49	-
296	N-linked_Glycosylation	FHLESVINITANLSS EEEEEEEEEECCCCC	24.33	-
300	N-linked_Glycosylation	SVINITANLSSTKDL EEEEEECCCCCHHHH	31.63	-
426	N-linked_Glycosylation	CMDVKTTNLTSGQYL CEECCCCCCCCHHHH	46.70	-
439	N-linked_Glycosylation	YLSRFLANTTFRGLS HHHHHHHCCCCCCCC	41.62	-
549	N-linked_Glycosylation	LCLDPMTNDSSMLDR EEECCCCCCHHHHHH	40.70	-
565	N-linked_Glycosylation	FSSLHSSNDTVPIKF HHHHHCCCCCCCCCC	52.57	-
886	N-linked_Glycosylation	PNSPLTSNISELISQ CCCCCCCCHHHHHHH	36.25	-
985	Phosphorylation	RFHRALNTSFVEEKQ HHHHHHHCCHHCCCC	25.13	25403869
986	Phosphorylation	FHRALNTSFVEEKQP HHHHHHCCHHCCCCC	26.65	25403869

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NMD3A_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NMD3A_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NMD3A_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of NMD3A_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.