NMD3A_HUMAN - dbPTM
NMD3A_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NMD3A_HUMAN
UniProt AC Q8TCU5
Protein Name Glutamate receptor ionotropic, NMDA 3A
Gene Name GRIN3A
Organism Homo sapiens (Human).
Sequence Length 1115
Subcellular Localization Cell membrane
Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Enriched in postsynaptic plasma membrane and postsynaptic densities. Requires th
Protein Description NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism (By similarity)..
Protein Sequence MRRLSLWWLLSRVCLLLPPPCALVLAGVPSSSSHPQPCQILKRIGHAVRVGAVHLQPWTTAPRAASRAPDDSRAGAQRDEPEPGTRRSPAPSPGARWLGSTLHGRGPPGSRKPGEGARAEALWPRDALLFAVDNLNRVEGLLPYNLSLEVVMAIEAGLGDLPLLPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMMELDLVSLVLHIPVISIVRHEFPRESQNPLHLQLSLENSLSSDADVTVSILTMNNWYNFSLLLCQEDWNITDFLLLTQNNSKFHLGSIINITANLPSTQDLLSFLQIQLESIKNSTPTVVMFGCDMESIRRIFEITTQFGVMPPELRWVLGDSQNVEELRTEGLPLGLIAHGKTTQSVFEHYVQDAMELVARAVATATMIQPELALIPSTMNCMEVETTNLTSGQYLSRFLANTTFRGLSGSIRVKGSTIVSSENNFFIWNLQHDPMGKPMWTRLGSWQGGKIVMDYGIWPEQAQRHKTHFQHPSKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEKIAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLRGTAHMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAVFLTLYEWKSPFGLTPKGRNRSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDKWYRVVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLLPRIKNKSKLQYWLHTSQRLHRAINTSFIEEKQQHFKTKRVEKRSNVGPRQLTVWNTSNLSHDNRRKYIFSDEEGQNQLGIRIHQDIPLPPRRRELPALRTTNGKADSLNVSRNSVMQELSELEKQIQVIRQELQLAVSRKTELEEYQRTSRTCES
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
72PhosphorylationASRAPDDSRAGAQRD
HHCCCCCCCCCCCCC		31.2628674151
145N-linked_GlycosylationVEGLLPYNLSLEVVM
CCCCCCCCCCHHHHH		22.63UniProtKB CARBOHYD
222PhosphorylationVLHIPVISIVRHEFP
HHHCHHHHHHCCCCC		18.4424719451
264N-linked_GlycosylationLTMNNWYNFSLLLCQ
EECCCCCCEEEEEEC		16.20UniProtKB CARBOHYD
275N-linked_GlycosylationLLCQEDWNITDFLLL
EEECCCCCCCCEEEE		39.34UniProtKB CARBOHYD
285N-linked_GlycosylationDFLLLTQNNSKFHLG
CEEEEECCCCCEECC		49.89UniProtKB CARBOHYD
296N-linked_GlycosylationFHLGSIINITANLPS
EECCCEEEEECCCCC		24.72UniProtKB CARBOHYD
321PhosphorylationQLESIKNSTPTVVMF
HHHHHCCCCCEEEEE		30.66-
322PhosphorylationLESIKNSTPTVVMFG
HHHHCCCCCEEEEEE		32.16-
426N-linked_GlycosylationCMEVETTNLTSGQYL
CEEEECCCCCCHHHH		49.06UniProtKB CARBOHYD
439N-linked_GlycosylationYLSRFLANTTFRGLS
HHHHHHHCCCCCCCC		41.62UniProtKB CARBOHYD
505PhosphorylationEQAQRHKTHFQHPSK
HHHHHHHHCCCCCCC		23.0723090842
549N-linked_GlycosylationLCLDPMTNDSSTLDS
EEECCCCCCHHHHHH		40.70UniProtKB CARBOHYD
565N-linked_GlycosylationFSSLHSSNDTVPIKF
HHHHHCCCCCCCCEE		52.57UniProtKB CARBOHYD
758PhosphorylationIFCMFCLSTYTANLA
HHHHHHHHHHHHHHH		22.1328348404
759PhosphorylationFCMFCLSTYTANLAA
HHHHHHHHHHHHHHH		16.3728348404
761PhosphorylationMFCLSTYTANLAAVM
HHHHHHHHHHHHHHH		14.7928348404
825PhosphorylationRRYNVPATPDGVEYL
HHCCCCCCCCCCHHH		18.8222964224
831PhosphorylationATPDGVEYLKNDPEK
CCCCCCHHHHCCHHH		22.1422964224
886N-linked_GlycosylationPNSPLTANISELISQ
CCCCCCCCHHHHHHH		32.84UniProtKB CARBOHYD
971PhosphorylationKNKSKLQYWLHTSQR
CCHHHHHHHHHHHHH		22.0029083192
975PhosphorylationKLQYWLHTSQRLHRA
HHHHHHHHHHHHHHH		25.1229083192
976PhosphorylationLQYWLHTSQRLHRAI
HHHHHHHHHHHHHHH		11.5329083192
1020PhosphorylationVWNTSNLSHDNRRKY
EEECCCCCCCCCCCE		32.8022210691
1067PhosphorylationTTNGKADSLNVSRNS
CCCCCCCCCCCCHHH		27.06-
1106PhosphorylationRKTELEEYQRTSRTC
CHHHHHHHHHHHCCC		8.23-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NMD3A_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NMD3A_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NMD3A_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of NMD3A_HUMAN !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NMD3A_HUMAN

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Related Literatures of Post-Translational Modification

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