NLRP9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NLRP9_HUMAN
• UniProt AC: Q7RTR0
• Protein Name: NACHT, LRR and PYD domains-containing protein 9
• Gene Name: NLRP9
• Organism: Homo sapiens (Human).
• Sequence Length: 991
• Subcellular Localization: Cytoplasm . Inflammasome .
• Protein Description: As the sensor component of the NLRP9 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens, including rotavirus, initiates the formation of the inflammasome polymeric complex, made of NLRP9, PYCARD and CASP1. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and release in the extracellular milieu. The active cytokines stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death. NLRP9 inflammasome activation may be initiated by DHX9 interaction with viral double-stranded RNA (dsRNA), preferentially to short dsRNA segments..
• Protein Sequence: MAESFFSDFGLLWYLKELRKEEFWKFKELLKQPLEKFELKPIPWAELKKASKEDVAKLLDKHYPGKQAWEVTLNLFLQINRKDLWTKAQEEMRNKLNPYRKHMKETFQLIWEKETCLHVPEHFYKETMKNEYKELNDAYTAAARRHTVVLEGPDGIGKTTLLRKVMLDWAEGNLWKDRFTFVFFLNVCEMNGIAETSLLELLSRDWPESSEKIEDIFSQPERILFIMDGFEQLKFNLQLKADLSDDWRQRQPMPIILSSLLQKKMLPESSLLIALGKLAMQKHYFMLRHPKLIKLLGFSESEKKSYFSYFFGEKSKALKVFNFVRDNGPLFILCHNPFTCWLVCTCVKQRLERGEDLEINSQNTTYLYASFLTTVFKAGSQSFPPKVNRARLKSLCALAAEGIWTYTFVFSHGDLRRNGLSESEGVMWVGMRLLQRRGDCFAFMHLCIQEFCAAMFYLLKRPKDDPNPAIGSITQLVRASVVQPQTLLTQVGIFMFGISTEEIVSMLETSFGFPLSKDLKQEITQCLESLSQCEADREAIAFQELFIGLFETQEKEFVTKVMNFFEEVFIYIGNIEHLVIASFCLKHCQHLTTLRMCVENIFPDDSGCISDYNEKLVYWRELCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLIFTSVYFGHDSELFKAVLHNPHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIASVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQKILMSVEEKIPHLTISHGPWIDEEYKIRGVLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MAESFFSDFGL ----CCCCHHCHHHH		30631047
7	Phosphorylation	-MAESFFSDFGLLWY -CCCCHHCHHHHHHH		30631047
139	Phosphorylation	YKELNDAYTAAARRH HHHHHHHHHHHHHCC		23312004
140	Phosphorylation	KELNDAYTAAARRHT HHHHHHHHHHHHCCE		23312004
160	Phosphorylation	PDGIGKTTLLRKVML CCCCCHHHHHHHHHH		24260401
203	Phosphorylation	TSLLELLSRDWPESS HHHHHHHCCCCCCHH		24719451
259	Phosphorylation	PMPIILSSLLQKKML CHHHHHHHHHHHCCC		24719451
269	Phosphorylation	QKKMLPESSLLIALG HHCCCCHHHHHHHHH		24275569
270	Phosphorylation	KKMLPESSLLIALGK HCCCCHHHHHHHHHH		24275569
303	Acetylation	LGFSESEKKSYFSYF HCCCHHHCCHHHHHH		20167786
304	Acetylation	GFSESEKKSYFSYFF CCCHHHCCHHHHHHH		20167786
314	Acetylation	FSYFFGEKSKALKVF HHHHHCCCCCCEEEE		18604493
316	Acetylation	YFFGEKSKALKVFNF HHHCCCCCCEEEEEE		24848065
691	Phosphorylation	NPHLKLLSLYGTSLS CHHHHHHHHHCCCCC		-
693	Phosphorylation	HLKLLSLYGTSLSQS HHHHHHHHCCCCCHH		-
952	Phosphorylation	QMLGLHKSGFDEETQ HHHCCCCCCCCHHHH		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NLRP9_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NLRP9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NLRP9_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PSD12_HUMAN	PSMD12	physical	26344197

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.