NLRC5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NLRC5_HUMAN
• UniProt AC: Q86WI3
• Protein Name: Protein NLRC5
• Gene Name: NLRC5
• Organism: Homo sapiens (Human).
• Sequence Length: 1866
• Subcellular Localization: Cytoplasm .
• Protein Description: Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms..
• Protein Sequence: MDPVGLQLGNKNLWSCLVRLLTKDPEWLNAKMKFFLPNTDLDSRNETLDPEQRVILQLNKLHVQGSDTWQSFIHCVCMQLEVPLDLEVLLLSTFGYDDGFTSQLGAEGKSQPESQLHHGLKRPHQSCGSSPRRKQCKKQQLELAKKYLQLLRTSAQQRYRSQIPGSGQPHAFHQVYVPPILRRATASLDTPEGAIMGDVKVEDGADVSISDLFNTRVNKGPRVTVLLGKAGMGKTTLAHRLCQKWAEGHLNCFQALFLFEFRQLNLITRFLTPSELLFDLYLSPESDHDTVFQYLEKNADQVLLIFDGLDEALQPMGPDGPGPVLTLFSHLCNGTLLPGCRVMATSRPGKLPACLPAEAAMVHMLGFDGPRVEEYVNHFFSAQPSREGALVELQTNGRLRSLCAVPALCQVACLCLHHLLPDHAPGQSVALLPNMTQLYMQMVLALSPPGHLPTSSLLDLGEVALRGLETGKVIFYAKDIAPPLIAFGATHSLLTSFCVCTGPGHQQTGYAFTHLSLQEFLAALHLMASPKVNKDTLTQYVTLHSRWVQRTKARLGLSDHLPTFLAGLASCTCRPFLSHLAQGNEDCVGAKQAAVVQVLKKLATRKLTGPKVVELCHCVDETQEPELASLTAQSLPYQLPFHNFPLTCTDLATLTNILEHREAPIHLDFDGCPLEPHCPEALVGCGQIENLSFKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKALPLCPQLKEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSICVSTLLCLARVAVTCPTVRMLQAREADLIFLLSPPTETTAELQRAPDLQESDGQRKGAQSRSLTLRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLSNNGLSVAGVHCVLRAVSACWTLAELHISLQHKTVIFMFAQEPEEQKGPQERAAFLDSLMLQMPSELPLSSRRMRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEGAARLAQLLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISFESQHILLRGDKTSRDMWATGSLPDFPAAAKFLGFRQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPLELQLSCEFLSDQSLETLLDCLPQLPQLSLLQLSQTGLSPKSPFLLANTLSLCPRVKKVDLRSLHHATLHFRSNEEEEGVCCGRFTGCSLSQEHVESLCWLLSKCKDLSQVDLSANLLGDSGLRCLLECLPQVPISGLLDLSHNSISQESALYLLETLPSCPRVREASVNLGSEQSFRIHFSREDQAGKTLRLSECSFRPEHVSRLATGLSKSLQLTELTLTQCCLGQKQLAILLSLVGRPAGLFSLRVQEPWADRARVLSLLEVCAQASGSVTEISISETQQQLCVQLEFPRQEENPEAVALRLAHCDLGAHHSLLVGQLMETCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTALGLAQELPQHLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLAGGVLRFCMELPLLRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMGRLKRVDLEKNQITALGAWLLAEGLAQGSSIQVIRLWNNPIPCDMAQHLKSQEPRLDFAFFDNQPQAPWGT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
126	Phosphorylation	GLKRPHQSCGSSPRR CCCCCCCCCCCCHHH	19.88	22210691
130	Phosphorylation	PHQSCGSSPRRKQCK CCCCCCCCHHHHHHH	14.01	24425749
138	Ubiquitination	PRRKQCKKQQLELAK HHHHHHHHHHHHHHH	51.40	-
185	Phosphorylation	PPILRRATASLDTPE CHHHHHCEECCCCCC	18.24	-
187	Phosphorylation	ILRRATASLDTPEGA HHHHCEECCCCCCCC	23.56	-
538	Phosphorylation	KVNKDTLTQYVTLHS CCCHHHHHHHHHHHH	21.68	29978859
540	Phosphorylation	NKDTLTQYVTLHSRW CHHHHHHHHHHHHHH	7.08	29978859
542	Phosphorylation	DTLTQYVTLHSRWVQ HHHHHHHHHHHHHHH	17.51	29978859
545	Phosphorylation	TQYVTLHSRWVQRTK HHHHHHHHHHHHHHH	30.83	29978859
692	Phosphorylation	CGQIENLSFKSRKCG CCCCCCCCCCCCCCH	42.06	24719451
697	Ubiquitination	NLSFKSRKCGDAFAE CCCCCCCCCHHHHHH	50.05	-
727	Phosphorylation	GLAGSKITARGISHL HHCCCCCHHHHHHHH	17.65	28348404
732	Phosphorylation	KITARGISHLVKALP CCHHHHHHHHHHHHH	17.37	28348404
911	Phosphorylation	DLSNNGLSVAGVHCV CCCCCCCCHHHHHHH	16.00	26330541
923	Phosphorylation	HCVLRAVSACWTLAE HHHHHHHHHHHHHHH	19.41	-
976	Phosphorylation	PSELPLSSRRMRLTH CCCCCCCCCCHHHHH	31.43	-
989	Ubiquitination	THCGLQEKHLEQLCK HHHCCCHHHHHHHHH	40.29	-
996	Ubiquitination	KHLEQLCKALGGSCH HHHHHHHHHHCCCCE	56.06	-
1099	Ubiquitination	PDFPAAAKFLGFRQR CCCHHHHHHHCCCCH	36.07	-
1179	Phosphorylation	QTGLSPKSPFLLANT HCCCCCCCHHHHHHH	25.03	23663014
1186	Phosphorylation	SPFLLANTLSLCPRV CHHHHHHHHHHCCCC	16.47	23663014
1188	Phosphorylation	FLLANTLSLCPRVKK HHHHHHHHHCCCCCC	26.36	23663014
1223	Phosphorylation	GVCCGRFTGCSLSQE CEECCCCCCCCCCHH	35.60	28450419
1226	Phosphorylation	CGRFTGCSLSQEHVE CCCCCCCCCCHHHHH	32.19	28450419
1228	Phosphorylation	RFTGCSLSQEHVESL CCCCCCCCHHHHHHH	19.75	28450419
1234	Phosphorylation	LSQEHVESLCWLLSK CCHHHHHHHHHHHHH	27.95	28450419
1240	Phosphorylation	ESLCWLLSKCKDLSQ HHHHHHHHHCCCHHH	33.56	28450419
1241	Ubiquitination	SLCWLLSKCKDLSQV HHHHHHHHCCCHHHC	45.32	-
1243	Ubiquitination	CWLLSKCKDLSQVDL HHHHHHCCCHHHCCC	66.49	-
1305	Phosphorylation	CPRVREASVNLGSEQ CCCEEEEEEECCCCC	13.54	27732954
1310	Phosphorylation	EASVNLGSEQSFRIH EEEEECCCCCEEEEE	35.31	27732954
1313	Phosphorylation	VNLGSEQSFRIHFSR EECCCCCEEEEEEEH	16.67	27732954
1349	Ubiquitination	RLATGLSKSLQLTEL HHHHHCCHHHCCCHH	61.29	-
1359	Phosphorylation	QLTELTLTQCCLGQK CCCHHHHHHHHHCHH	17.83	-
1549	Ubiquitination	LMRALEGKWMLKRLD HHHHHCCCHHHHHCC	21.76	-
1558	Phosphorylation	MLKRLDLSHLLLNSS HHHHCCHHHHHHCHH	16.26	-
1564	Phosphorylation	LSHLLLNSSTLALLT HHHHHHCHHHHHHHH	25.35	-
1751	Ubiquitination	QIDLVSCKIDNQTAK HCEEEEEEECHHHHH	45.66	-
1845	Ubiquitination	CDMAQHLKSQEPRLD CCHHHHHHHCCCCCC	48.22	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NLRC5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NLRC5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NLRC5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IKKB_HUMAN	IKBKB	physical	20434986
IKKA_HUMAN	CHUK	physical	20434986
DDX58_HUMAN	DDX58	physical	20434986
IFIH1_HUMAN	IFIH1	physical	20434986

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.