NKX23_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NKX23_MOUSE
• UniProt AC: P97334
• Protein Name: Homeobox protein Nkx-2.3
• Gene Name: Nkx2-3
• Organism: Mus musculus (Mouse).
• Sequence Length: 362
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional regulator essential for normal development and functions of the small intestine and spleen. Activates directly MADCAM1 expression. Required for homing of lymphocytes in spleen and mucosa-associated lymphoid tissue. May have a role during pharyngeal organogenesis..
• Protein Sequence: MMLPSPVTSTPFSVKDILNLEQQRHFHGAHLQAELEQHFHSAPCMLATAEGTQFSDAGEEDEEEEGEKLSYLNSLAAAEGHGDSGLCPQSYVHTVLRDACSGPKEQEEEVVSERSQKSCQLKKSLEAAGDCKTSEDGERPKPRSRRKPRVLFSQAQVFELERRFKQQRYLSAPEREHLASSLKLTSTQVKIWFQNRRYKCKRQRQDKSLELGTHAPPPPPRRVAVPVLVRDGKPCVTPSAQTYGSPYGVGAGAYSYNSFPAYGYGNSAAAAAAAAAAAAAAAAYSGSYGCAYPTGGGGGGGGTASAATTAMQPACSATGGGSFVNVSNLGGFGSGGGAQPLHQGAAAGSACTQGTLQGIRAW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
208	Phosphorylation	KRQRQDKSLELGTHA HHHHCCCCCCCCCCC	35.05	21659604
213	Phosphorylation	DKSLELGTHAPPPPP CCCCCCCCCCCCCCC	27.73	21659604

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NKX23_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NKX23_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NKX23_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.