dbPTM

NKAPL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NKAPL_HUMAN
UniProt AC	Q5M9Q1
Protein Name	NKAP-like protein
Gene Name	NKAPL
Organism	Homo sapiens (Human).
Sequence Length	402
Subcellular Localization	Nucleus .
Protein Description	Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis..
Protein Sequence	MPPVSRSSYSEDIVGSRRRRRSSSGSPPSPQSRCSSWDGCSRSHSRGREGLRPPWSELDVGALYPFSRSGSRGRLPRFRNYAFASSWSTSYSGYRYHRHCYAEERQSAEDYEKEESHRQRRLKERERIGELGAPEVWGPSPKFPQLDSDEHTPVEDEEEVTHQKSSSSDSNSEEHRKKKTSRSRNKKKRKNKSSKRKHRKYSDSDSNSESDTNSDSDDDKKRVKAKKKKKKKKHKTKKKKNKKTKKESSDSSCKDSEEDLSEATWMEQPNVADTMDLIGPEAPIIHTSQDEKPLKYGHALLPGEGAAMAEYVKAGKRIPRRGEIGLTSEEIGSFECSGYVMSGSRHRRMEAVRLRKENQIYSADEKRALASFNQEERRKRESKILASFREMVHKKTKEKDDK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MPPVSRSSYSED ---CCCCCHHHCCCC	32.02	29209046
7	Phosphorylation	-MPPVSRSSYSEDIV -CCCCCHHHCCCCCC	26.56	29209046
8	Phosphorylation	MPPVSRSSYSEDIVG CCCCCHHHCCCCCCC	31.41	29209046
9	Phosphorylation	PPVSRSSYSEDIVGS CCCCHHHCCCCCCCC	19.82	29209046
10	Phosphorylation	PVSRSSYSEDIVGSR CCCHHHCCCCCCCCC	30.64	29209046
16	Phosphorylation	YSEDIVGSRRRRRSS CCCCCCCCCCCCCCC	16.24	29209046
22	Phosphorylation	GSRRRRRSSSGSPPS CCCCCCCCCCCCCCC	27.35	22798277
23	Phosphorylation	SRRRRRSSSGSPPSP CCCCCCCCCCCCCCC	36.59	22798277
24	Phosphorylation	RRRRRSSSGSPPSPQ CCCCCCCCCCCCCCC	44.53	22798277
26	Phosphorylation	RRRSSSGSPPSPQSR CCCCCCCCCCCCCCC	35.27	27251275
91	Phosphorylation	ASSWSTSYSGYRYHR CCCCCCCCCCCCCEE	13.25	-
92	Phosphorylation	SSWSTSYSGYRYHRH CCCCCCCCCCCCEEE	29.17	-
94	Phosphorylation	WSTSYSGYRYHRHCY CCCCCCCCCCEEECC	11.32	-
140	Phosphorylation	APEVWGPSPKFPQLD CCCCCCCCCCCCCCC	36.46	24961811
148	Phosphorylation	PKFPQLDSDEHTPVE CCCCCCCCCCCCCCC	54.19	-
152	Phosphorylation	QLDSDEHTPVEDEEE CCCCCCCCCCCCHHH	27.29	22817900
166	Phosphorylation	EVTHQKSSSSDSNSE HHHCCCCCCCCCCHH	40.68	-
201	Phosphorylation	SKRKHRKYSDSDSNS HHHHHHCCCCCCCCC	20.05	24114839
202	Phosphorylation	KRKHRKYSDSDSNSE HHHHHCCCCCCCCCC	33.40	24114839
206	Phosphorylation	RKYSDSDSNSESDTN HCCCCCCCCCCCCCC	46.32	24114839
208	Phosphorylation	YSDSDSNSESDTNSD CCCCCCCCCCCCCCC	42.29	24114839
212	Phosphorylation	DSNSESDTNSDSDDD CCCCCCCCCCCCHHH	45.99	-
214	Phosphorylation	NSESDTNSDSDDDKK CCCCCCCCCCHHHHH	40.35	-
233	Acetylation	KKKKKKKKHKTKKKK HHHHHHHHHHHHHHH	60.25	7709739
311	Phosphorylation	EGAAMAEYVKAGKRI CCHHHHHHHHCCCCC	9.56	-
313	Ubiquitination	AAMAEYVKAGKRIPR HHHHHHHHCCCCCCC	50.98	29967540
337	Phosphorylation	EIGSFECSGYVMSGS HCCCEEECEEEEECC	26.43	-
339	Phosphorylation	GSFECSGYVMSGSRH CCEEECEEEEECCHH	4.08	-
342	Phosphorylation	ECSGYVMSGSRHRRM EECEEEEECCHHHHH	24.47	-
344	Phosphorylation	SGYVMSGSRHRRMEA CEEEEECCHHHHHHH	20.01	-
361	Phosphorylation	LRKENQIYSADEKRA HHHHCCCCCHHHHHH	6.50	30576142
362	Phosphorylation	RKENQIYSADEKRAL HHHCCCCCHHHHHHH	30.76	21815630
366	Ubiquitination	QIYSADEKRALASFN CCCCHHHHHHHHHCC	43.44	24816145
387	Phosphorylation	RESKILASFREMVHK HHHHHHHHHHHHHHH	22.76	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NKAPL_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NKAPL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
152	Phosphorylation	152 (0)	T ⇒ I;N	rs1635	Schizophrenia	22037552

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of NKAPL_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NKAPL_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-362, AND MASSSPECTROMETRY.	19413330 [Abstract]