NIPA4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NIPA4_HUMAN
• UniProt AC: Q0D2K0
• Protein Name: Magnesium transporter NIPA4
• Gene Name: NIPAL4
• Organism: Homo sapiens (Human).
• Sequence Length: 466
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Mn(2+), Sr(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity). May be a receptor for ligands (trioxilins A3 and B3) from the hepoxilin pathway..
• Protein Sequence: MPGDSSPGTLPLWDASLSPPLGPDPGGFSRASHAGDKSRPPAPELGSPGAVRPRVGSCAPGPMELRVSNTSCENGSLLHLYCSSQEVLCQIVNDLSPEVPSNATFHSWQERIRQNYGFYIGLGLAFLSSFLIGSSVILKKKGLLRLVATGATRAVDGGFGYLKDAMWWAGFLTMAAGEVANFGAYAFAPATVVTPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVIHAPEEEKVTTIMEMASKMKDTGFIVFAVLLLVSCLILIFVIAPRYGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLPVVRHPLPYILSLILALSLSTQVNFLNRALDIFNTSLVFPIYYVFFTTVVVTSSIILFKEWYSMSAVDIAGTLSGFVTIILGVFMLHAFKDLDISCASLPHMHKNPPPSPAPEPTVIRLEDKNVLVDNIELASTSSPEEKPKVFIIHS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
69	N-linked_Glycosylation	PMELRVSNTSCENGS CEEEEEECCCCCCCC	32.90	UniProtKB CARBOHYD
74	N-linked_Glycosylation	VSNTSCENGSLLHLY EECCCCCCCCEEEEE	50.08	UniProtKB CARBOHYD
102	N-linked_Glycosylation	LSPEVPSNATFHSWQ CCCCCCCCCCCHHHH	36.61	UniProtKB CARBOHYD
427	Phosphorylation	MHKNPPPSPAPEPTV CCCCCCCCCCCCCCE	39.19	30266825
433	Phosphorylation	PSPAPEPTVIRLEDK CCCCCCCCEEEECCC	27.23	30266825
451	Phosphorylation	VDNIELASTSSPEEK EEEEEEECCCCCCCC	41.25	30108239
452	Phosphorylation	DNIELASTSSPEEKP EEEEEECCCCCCCCC	27.84	30108239
453	Phosphorylation	NIELASTSSPEEKPK EEEEECCCCCCCCCC	41.21	30108239
454	Phosphorylation	IELASTSSPEEKPKV EEEECCCCCCCCCCE	36.10	24245541

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NIPA4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NIPA4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NIPA4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of NIPA4_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.