NHX5_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NHX5_ARATH
• UniProt AC: Q8S396
• Protein Name: Sodium/hydrogen exchanger 5
• Gene Name: NHX5
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 521
• Subcellular Localization: Endosome membrane ; Multi-pass membrane protein . Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein . Golgi apparatus, Golgi stack membrane ; Multi-pass membrane protein .
• Protein Description: Involved in trafficking to the vacuole. Required for cell proliferation and cell expansion, but not for cell differentiation. Acts in low affinity electroneutral exchange of protons for cations such as Na(+) or K(+) across membranes. May also exchange Li(+) and Cs(+) with a lower affinity..
• Protein Sequence: MEEVMISPVEHDPQGQVKQQQAAGVGILLQIMMLVLSFVLGHVLRRHRFHYLPEASGSLLIGLIVGILANISDTETSIRTWFNFHEEFFFLFLLPPIIFQSGFSLQPKPFFSNFGAIVTFAIIGTFVASVVTGGLVYLGGSMYLMYKLPFVECLMFGALISATDPVTVLSIFQDVGTDVNLYALVFGESVLNDAMAISLYRTMSLVNRQSSSGEHFFMVVIRFFETFAGSMSAGVGVGFTSALLFKYAGLDTENLQNLECCLFVLFPYFSYMLAEGVGLSGIVSILFTGIVMKRYTFSNLSEASQSFVSSFFHLISSLAETFTFIYMGFDIAMEQHSWSHVGFILFSILFIGVARAVNVFGCAYLVNLFRQENQKIPMKHQKALWYSGLRGAMAFALALQSLHDLPEGHGQIIFTATTTIVVVTVLLIGGSTGKMLEALEVVGDDLDDSMSEGFEESDHQYVPPPFSIGASSDEDTSSSGSRFKMKLKEFHKTTTSFTALDKNFLTPFFTTNSGDGDGDGE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
280	Phosphorylation	LAEGVGLSGIVSILF HHHCCCHHHHHHHHH	22.12	28011693
299	N-linked_Glycosylation	MKRYTFSNLSEASQS HHCCCCCCHHHHHHH	43.31	-
496	Phosphorylation	EFHKTTTSFTALDKN HHHCCCCCEEECCCC	20.64	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NHX5_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NHX5_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NHX5_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CNG13_ARATH	CNGC13	physical	22737156
PTR2_ARATH	PTR2	physical	22737156
NHX6_ARATH	NHX6	genetic	26416852

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.