NHRF1_RABIT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NHRF1_RABIT
• UniProt AC: Q28619
• Protein Name: Na(+)/H(+) exchange regulatory cofactor NHE-RF1
• Gene Name: SLC9A3R1
• Organism: Oryctolagus cuniculus (Rabbit).
• Sequence Length: 358
• Subcellular Localization: Cytoplasm. Apical cell membrane. Cell projection, filopodium. Cell projection, ruffle. Cell projection, microvillus. Endomembrane system; Peripheral membrane protein. Colocalizes with actin in microvilli-rich apical regions of the syncytiotrophoblast
• Protein Description: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules (By similarity)..
• Protein Sequence: MSADAAAGAPLPRLCCLEKGPNGYGFHLHGEKGKVGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQVVSRIRAALNAVRLLVVDPDTDEQFRKLGVQIRGELLRAQAGPEQAGPPAAPGEQGPAGENEPREVEKSHPERRELRPRLCAMKKGPNGYGFNLHSDKSRPGQFIRAVDPDSPAEASGLREQDRIVEVNGVCVEGKQHGDVVTAIKAGGDEAKLLVVDKETDEFFKKCKVVPSSEHLNGPLPEPFTNGEIQKNNPETLAPAASESPRPALARSASSDTSEELASQDSPKKEDSTAPSSTSSSSDPILDFSISLAVAKERAHQKRSSRRAPQMDWSEKKELFSNL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSADAAAGA ------CCHHHHCCC	34.55	-
2	Phosphorylation	------MSADAAAGA ------CCHHHHCCC	34.55	-
46	Phosphorylation	IRLVEPGSPAEKAGL EEEECCCCHHHHHCC	31.49	-
279	Phosphorylation	LAPAASESPRPALAR CCCCCCCCCCHHHHH	24.58	-
287	Phosphorylation	PRPALARSASSDTSE CCHHHHHCCCCCCHH	27.22	-
289	Phosphorylation	PALARSASSDTSEEL HHHHHCCCCCCHHHH	29.96	10455146
290	Phosphorylation	ALARSASSDTSEELA HHHHCCCCCCHHHHH	44.62	10455146
292	Phosphorylation	ARSASSDTSEELASQ HHCCCCCCHHHHHCC	39.73	-
293	Phosphorylation	RSASSDTSEELASQD HCCCCCCHHHHHCCC	33.78	-
298	Phosphorylation	DTSEELASQDSPKKE CCHHHHHCCCCCCCC	47.33	-
301	Phosphorylation	EELASQDSPKKEDST HHHHCCCCCCCCCCC	30.86	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
289	S	Phosphorylation	Kinase	GRK6	P43250	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NHRF1_RABIT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NHRF1_RABIT !!

Protein-Protein Interaction

Oops, there are no PPI records of NHRF1_RABIT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.