NFRKB_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NFRKB_MOUSE
• UniProt AC: Q6PIJ4
• Protein Name: Nuclear factor related to kappa-B-binding protein
• Gene Name: Nfrkb
• Organism: Mus musculus (Mouse).
• Sequence Length: 1296
• Subcellular Localization: Nucleus.
• Protein Description: Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'.; Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex (By similarity)..
• Protein Sequence: MDSLDHMLTDPLELGPCGDGHSTGIMEDCLLGGTRVSLPEDLLEDPEIFFDVVSLSTWQEVLSDSQREHLQQFLPRFPADSVEQQRELILALFSGENFRFGNPLHIAQKLFRDGHFNPEVVKYRQLCFKSQYKRYLNSQQQYFHRLLKQILASRSDLLEMARRSGPALPFPHKHHSPSRSPEEREWRTQQRYLKVLREVKEECGDTALSSDEEDLSSWLPSSPARSPSPAVPLRVVPTLSTTDMKTADKIELGDSDLKLMLKKHHEKRKHQPDHPDLLTGDLTLSDIMTRVNAGRKGSLAALYDLAVLKKKVKEKEEKKKKKIKLIKSEAEDLAEPLSSTEGVPTLSQAPSPLAISSIKEEPLEDIKPCLGINEISSSFFSLLLEILLLESQASLPMLEDRVLDWQSSPASSLNSWFSAAPNWAELVLPALQYLAGESRAVPSSFSPFVEFKEKTQQWKLLGQSQDNEKELAALFHLWLETKDQAFCKENEDSSDAMTPVPRVRTDYVVRPSTGEEKRVFQEQERYRYSQPHKAFTFRMHGFESVVGPVKGVFDKETSLNKAREHSLLRSDRPAYVTILSLVRDAAARLPNGEGTRAEICELLKDSQFLAPDVTSTQVNTVVSGALDRLHYEKDPCVKYDIGRKLWIYLHRDRSEEEFERIHQAQAAAAKARKALQQKPKPPSKVKSSNKEGSTKGLSGPSEQSQMSLSDSSMPPTPVTPVTPTTPALPTPISPPPVSAVNRSGSSTVSEPAQSSSGVLLVSSPTMPQLGTMLSPASIQTPPSSQATARVVSHSSSAGLPQVRVVAQPSLPAVSQQSVGPAQPLPQMPAGPQIRVPVTATQTKVVPQAVMATVPVKGQTAAASVQRPGPGQTGLTVTNLPAAVSPVSKTAMSSPGNSAPSASTTAVIQNVTGQNIIKQVSITGQLGVKPQTGSSIPLTATNFRIQGKDVLRLPPSSITTDAKGQTVLRITPDMMATLAKSQVTTVKLTQDLFGAGSGTAGKGISATLHVTSNPVHAADSPAKAPSASVPSSAPAGTTVVKVTPDLKPTETANSAFRLMPALGVSVADQKGKNTVASSEAKPAATIRIVQGLGVMPPKAGQTITVAAHAKQGASVAGGSGTVHSSTVSLPSINAAVSKTVAVASGATSTPISIGTGAPTVRQVPVNTTVVSTSQSGKLPTRITVPLSVISQPMKGKSVVTAPIIKGNLGANLSGLGRNIILTTMPAGTKLIAGNKPVSFLTAQQLQQLQQQGQATQVRIQTVPASHLQQGTASGSSKAVSTVVVTTAPSPKQAPEQQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
176	Phosphorylation	PFPHKHHSPSRSPEE CCCCCCCCCCCCHHH	25.04	25159016
178	Phosphorylation	PHKHHSPSRSPEERE CCCCCCCCCCHHHHH	48.70	25159016
180	Phosphorylation	KHHSPSRSPEEREWR CCCCCCCCHHHHHHH	40.79	25159016
206	Phosphorylation	VKEECGDTALSSDEE HHHHHCCCCCCCCHH	18.12	21183079
210	Phosphorylation	CGDTALSSDEEDLSS HCCCCCCCCHHHHHH	50.30	21183079
216	Phosphorylation	SSDEEDLSSWLPSSP CCCHHHHHHHCCCCC	31.61	-
221	O-linked_Glycosylation	DLSSWLPSSPARSPS HHHHHCCCCCCCCCC	46.94	55412897
221	Phosphorylation	DLSSWLPSSPARSPS HHHHHCCCCCCCCCC	46.94	21183079
222	Phosphorylation	LSSWLPSSPARSPSP HHHHCCCCCCCCCCC	22.19	-
222	O-linked_Glycosylation	LSSWLPSSPARSPSP HHHHCCCCCCCCCCC	22.19	55412905
226	Phosphorylation	LPSSPARSPSPAVPL CCCCCCCCCCCCCCE	31.66	22942356
228	Phosphorylation	SSPARSPSPAVPLRV CCCCCCCCCCCCEEE	27.08	25521595
298	Phosphorylation	VNAGRKGSLAALYDL HHCCCCCHHHHHHHH	20.19	21082442
303	Phosphorylation	KGSLAALYDLAVLKK CCHHHHHHHHHHHHH	12.27	28833060
328	Phosphorylation	KKIKLIKSEAEDLAE HHCHHHHHHHHHHHH	34.74	25159016
338	Phosphorylation	EDLAEPLSSTEGVPT HHHHHCCCCCCCCCC	46.02	30635358
339	Phosphorylation	DLAEPLSSTEGVPTL HHHHCCCCCCCCCCH	37.85	30635358
340	Phosphorylation	LAEPLSSTEGVPTLS HHHCCCCCCCCCCHH	33.12	30635358
345	Phosphorylation	SSTEGVPTLSQAPSP CCCCCCCCHHCCCCC	36.31	25159016
347	Phosphorylation	TEGVPTLSQAPSPLA CCCCCCHHCCCCCCE	27.12	25159016
351	Phosphorylation	PTLSQAPSPLAISSI CCHHCCCCCCEECCC	35.25	27087446
356	Phosphorylation	APSPLAISSIKEEPL CCCCCEECCCCCCCH	22.02	25159016
357	Phosphorylation	PSPLAISSIKEEPLE CCCCEECCCCCCCHH	31.41	25159016
493	Phosphorylation	FCKENEDSSDAMTPV HHHCCCCCCCCCCCC	24.76	25521595
494	Phosphorylation	CKENEDSSDAMTPVP HHCCCCCCCCCCCCC	41.53	25266776
498	Phosphorylation	EDSSDAMTPVPRVRT CCCCCCCCCCCCEEC	23.90	26643407
577	Phosphorylation	SDRPAYVTILSLVRD CCCCHHHHHHHHHHH	11.97	19854140
580	Phosphorylation	PAYVTILSLVRDAAA CHHHHHHHHHHHHHH	22.44	19854140
687	Phosphorylation	KPPSKVKSSNKEGST CCCCCCCCCCCCCCC	41.97	28059163
796	Phosphorylation	RVVSHSSSAGLPQVR EEECCCCCCCCCEEE	29.39	27841257
859	Phosphorylation	TVPVKGQTAAASVQR CCCCCCEEEEEEECC	27.25	25619855
863	Phosphorylation	KGQTAAASVQRPGPG CCEEEEEEECCCCCC	17.66	25619855
872	Phosphorylation	QRPGPGQTGLTVTNL CCCCCCCCCEEEECC	39.82	25619855
875	Phosphorylation	GPGQTGLTVTNLPAA CCCCCCEEEECCCCE	26.99	25619855
877	Phosphorylation	GQTGLTVTNLPAAVS CCCCEEEECCCCEEC	26.29	25619855
884	Phosphorylation	TNLPAAVSPVSKTAM ECCCCEECCCCCCCC	18.17	25521595
887	Phosphorylation	PAAVSPVSKTAMSSP CCEECCCCCCCCCCC	27.89	25619855
889	Phosphorylation	AVSPVSKTAMSSPGN EECCCCCCCCCCCCC	21.78	26643407
892	Phosphorylation	PVSKTAMSSPGNSAP CCCCCCCCCCCCCCC	30.80	25293948
893	Phosphorylation	VSKTAMSSPGNSAPS CCCCCCCCCCCCCCC	24.60	25293948
897	Phosphorylation	AMSSPGNSAPSASTT CCCCCCCCCCCCCCE	47.69	25293948
900	Phosphorylation	SPGNSAPSASTTAVI CCCCCCCCCCCEEEE	34.27	25293948
902	Phosphorylation	GNSAPSASTTAVIQN CCCCCCCCCEEEEEE	30.54	25293948
903	Phosphorylation	NSAPSASTTAVIQNV CCCCCCCCEEEEEEC	20.63	25293948
904	Phosphorylation	SAPSASTTAVIQNVT CCCCCCCEEEEEECC	19.21	25293948
947	Acetylation	TNFRIQGKDVLRLPP ECEEECCEECEECCC	28.43	23806337
1019	Phosphorylation	NPVHAADSPAKAPSA CCCCCCCCCCCCCCC	23.25	26643407
1025	Phosphorylation	DSPAKAPSASVPSSA CCCCCCCCCCCCCCC	37.73	28285833
1027	Phosphorylation	PAKAPSASVPSSAPA CCCCCCCCCCCCCCC	38.61	28285833
1030	Phosphorylation	APSASVPSSAPAGTT CCCCCCCCCCCCCCE	36.66	28285833
1031	Phosphorylation	PSASVPSSAPAGTTV CCCCCCCCCCCCCEE	32.00	28285833
1048	Phosphorylation	VTPDLKPTETANSAF ECCCCCCCCCCCHHH	44.36	22802335
1053	Phosphorylation	KPTETANSAFRLMPA CCCCCCCHHHHHHHH	26.73	22802335
1080	Acetylation	TVASSEAKPAATIRI CCCCCCCCCCCEEEE	31.01	23954790
1120	Phosphorylation	SVAGGSGTVHSSTVS CCCCCCCCCCCCCCC	19.42	26060331
1123	Phosphorylation	GGSGTVHSSTVSLPS CCCCCCCCCCCCCCC	24.30	26060331
1124	Phosphorylation	GSGTVHSSTVSLPSI CCCCCCCCCCCCCCC	20.25	26060331
1125	Phosphorylation	SGTVHSSTVSLPSIN CCCCCCCCCCCCCCC	19.68	26060331
1127	Phosphorylation	TVHSSTVSLPSINAA CCCCCCCCCCCCCCE	34.35	26060331
1130	Phosphorylation	SSTVSLPSINAAVSK CCCCCCCCCCCEECC	33.49	26060331
1138	Phosphorylation	INAAVSKTVAVASGA CCCEECCEEEECCCC	13.24	26239621
1172	O-linked_Glycosylation	NTTVVSTSQSGKLPT CCEEEECCCCCCCCC	18.16	22517741
1196	Phosphorylation	SQPMKGKSVVTAPII CCCCCCCCEEECCEE	30.41	-
1199	Phosphorylation	MKGKSVVTAPIIKGN CCCCCEEECCEECCC	25.26	-
1212	Phosphorylation	GNLGANLSGLGRNII CCCCCCCCCCCCCEE	31.60	-
1234	Acetylation	TKLIAGNKPVSFLTA CEEECCCCCCCHHHH	45.97	23236377
1270	O-linked_Glycosylation	ASHLQQGTASGSSKA HHHHCCCCCCCCCCE	17.20	22517741
1279	Phosphorylation	SGSSKAVSTVVVTTA CCCCCEEEEEEEECC	21.97	28833060
1280	Phosphorylation	GSSKAVSTVVVTTAP CCCCEEEEEEEECCC	15.66	28833060
1284	Phosphorylation	AVSTVVVTTAPSPKQ EEEEEEEECCCCCCC	12.96	28833060
1285	Phosphorylation	VSTVVVTTAPSPKQA EEEEEEECCCCCCCC	25.59	28833060
1288	Phosphorylation	VVVTTAPSPKQAPEQ EEEECCCCCCCCCCC	42.12	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
351	S	Phosphorylation	Kinase	MTOR	Q9JLN9	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NFRKB_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NFRKB_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NFRKB_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.