NFM_CHICK - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NFM_CHICK
• UniProt AC: P16053
• Protein Name: Neurofilament medium polypeptide
• Gene Name: NEFM
• Organism: Gallus gallus (Chicken).
• Sequence Length: 858
• Protein Description: Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber..
• Protein Sequence: MSYTMEPLGNPSYRRVMTETRATYSRASASPSSGFRSQSWSRGSGSTVSSSYKRTNLGAPRTAYGSTVLSSAESLDVSQSSLLNGAAELKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAELAALRQKHAGRAQLGDAYEQELRELRGALEQVSHEKAQIQLDSEHIEEDIQRLRERFEDEARLRDETEATIAALRKEMEEASLMRAELDKKVQSLQDEVAFLRGNHEEEVAELLAQLQASHATVERKDYLKTDLTTALKEIRAQLECQSDHNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNNDLTTYQDTIHQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSAFSGSITGPIFTHRQPSVTIASTKIQKTKIEPPKLKVQHKFVEEIIEETKVEDEKSEMEDALSAIAEEMAAKAQEEEQEEEKAEEEAVEEEAVSEKAAEQAAEEEEKEEEEAEEEEAAKSDAAEEGGSKKEEIEEKEEGEEAEEEEAEAKGKAEEAGAKVEKVKSPPAKSPPKSPPKSPVTEQAKAVQKAAAEVGKDQKAEKAAEKAAKEEKAASPEKPATPKVTSPEKPATPEKPPTPEKAITPEKVRSPEKPTTPEKVVSPEKPASPEKPRTPEKPASPEKPATPEKPRTPEKPATPEKPRSPEKPSSPLKDEKAVVEESITVTKVTKVTAEVEVSKEARKEDIAVNGEVEEKKDEAKEKEAEEEEKGVVTNGLDVSPVDEKGEKVVVTKKAEKITSEGGDSTTTYITKSVTVTQKVEEHEESFEEKLVSTKKVEKVTSHAVVKEIKE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSYTMEPLG ------CCCCCCCCC	29.34	-
47	O-linked_Glycosylation	WSRGSGSTVSSSYKR CCCCCCCCCCCCCCC	28.12	-
427	O-linked_Glycosylation	THRQPSVTIASTKIQ CCCCCCEEEECCCEE	18.37	-
464	Phosphorylation	TKVEDEKSEMEDALS HCCCCCHHHHHHHHH	39.88	-
471	Phosphorylation	SEMEDALSAIAEEMA HHHHHHHHHHHHHHH	21.25	-
502	Phosphorylation	AVEEEAVSEKAAEQA HHHHHHHHHHHHHHH	40.19	-
528	Phosphorylation	EEEEAAKSDAAEEGG HHHHHHHHHHHHHCC	27.96	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
464	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
471	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
502	S	Phosphorylation	Kinase	CK1A	P48729	PSP
528	S	Phosphorylation	Kinase	CK1A	P48729	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NFM_CHICK !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NFM_CHICK !!

Protein-Protein Interaction

Oops, there are no PPI records of NFM_CHICK !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.