NEUS_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NEUS_HUMAN
• UniProt AC: Q99574
• Protein Name: Neuroserpin
• Gene Name: SERPINI1
• Organism: Homo sapiens (Human).
• Sequence Length: 410
• Subcellular Localization: Secreted . Cytoplasmic vesicle, secretory vesicle lumen . Perikaryon .
• Protein Description: Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. [PubMed: 9442076]
• Protein Sequence: MAFLGLFSLLVLQSMATGATFPEEAIADLSVNMYNRLRATGEDENILFSPLSIALAMGMMELGAQGSTQKEIRHSMGYDSLKNGEEFSFLKEFSNMVTAKESQYVMKIANSLFVQNGFHVNEEFLQMMKKYFNAAVNHVDFSQNVAVANYINKWVENNTNNLVKDLVSPRDFDAATYLALINAVYFKGNWKSQFRPENTRTFSFTKDDESEVQIPMMYQQGEFYYGEFSDGSNEAGGIYQVLEIPYEGDEISMMLVLSRQEVPLATLEPLVKAQLVEEWANSVKKQKVEVYLPRFTVEQEIDLKDVLKALGITEIFIKDANLTGLSDNKEIFLSKAIHKSFLEVNEEGSEAAAVSGMIAISRMAVLYPQVIVDHPFFFLIRNRRTGTILFMGRVMHPETMNTSGHDFEEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Phosphorylation	MYNRLRATGEDENIL HHHHHHCCCCCCCCC	34.37	24043423
49	Phosphorylation	EDENILFSPLSIALA CCCCCCCCHHHHHHH	22.83	24043423
52	Phosphorylation	NILFSPLSIALAMGM CCCCCHHHHHHHHHH	14.81	24043423
67	Phosphorylation	MELGAQGSTQKEIRH HHHCCCCCCHHHHHH	18.65	24043423
68	Phosphorylation	ELGAQGSTQKEIRHS HHCCCCCCHHHHHHH	50.95	24043423
88	Phosphorylation	LKNGEEFSFLKEFSN CCCCCCCCHHHHHHH	32.71	24719451
131	Phosphorylation	FLQMMKKYFNAAVNH HHHHHHHHHHHHHCC	9.13	19053533
150	Phosphorylation	QNVAVANYINKWVEN HHHHHHHHHHHHHHC	8.99	19053533
157	N-linked_Glycosylation	YINKWVENNTNNLVK HHHHHHHCCCCCHHH	51.51	UniProtKB CARBOHYD
203	Phosphorylation	PENTRTFSFTKDDES CCCCCEEEEECCCCC	31.24	24719451
258	Phosphorylation	ISMMLVLSRQEVPLA EEEEEEECCCCCCHH	25.16	24719451
313	Phosphorylation	VLKALGITEIFIKDA HHHHCCCCEEEEECC	22.64	-
321	N-linked_Glycosylation	EIFIKDANLTGLSDN EEEEECCCCCCCCCC	48.55	UniProtKB CARBOHYD
323	Phosphorylation	FIKDANLTGLSDNKE EEECCCCCCCCCCCH	35.56	-
401	N-linked_Glycosylation	VMHPETMNTSGHDFE ECCHHHCCCCCCCCC	38.21	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	AMFR	Q9UKV5	PMID:21507957

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NEUS_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NEUS_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of NEUS_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 604218: Encephalopathy, familial, with neuroserpin inclusion bodies (FENIB)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.