NEUA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NEUA_MOUSE
• UniProt AC: Q99KK2
• Protein Name: N-acylneuraminate cytidylyltransferase
• Gene Name: Cmas
• Organism: Mus musculus (Mouse).
• Sequence Length: 432
• Subcellular Localization: Nucleus .
• Protein Description: Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN)..
• Protein Sequence: MDALEKGAVTSGPAPRGRPSRGRPPKLQRSRGAGRGLEKPPHLAALVLARGGSKGIPLKNIKRLAGVPLIGWVLRAALDAGVFQSVWVSTDHDEIENVAKQFGAQVHRRSSETSKDSSTSLDAIVEFLNYHNEVDIVGNIQATSPCLHPTDLQKVAEMIREEGYDSVFSVVRRHQFRWSEIQKGVREVTEPLNLNPAKRPRRQDWDGELYENGSFYFAKRHLIEMGYLQGGKMAYYEMRAEHSVDIDVDIDWPIAEQRVLRFGYFGKEKLKEIKLLVCNIDGCLTNGHIYVSGDQKEIISYDVKDAIGISLLKKSGIEVRLISERACSKQTLSALKLDCKTEVSVSDKLATVDEWRKEMGLCWKEVAYLGNEVSDEECLKRVGLSAVPADACSGAQKAVGYICKCSGGRGAIREFAEHIFLLIEKVNNSCQK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDALEKGA -------CCHHHCCC	6.49	-
35	Methylation	QRSRGAGRGLEKPPH CCCCCCCCCCCCCHH	46.09	24129315
39	Ubiquitination	GAGRGLEKPPHLAAL CCCCCCCCCHHHHHH	69.74	-
39	Malonylation	GAGRGLEKPPHLAAL CCCCCCCCCHHHHHH	69.74	26320211
50	Methylation	LAALVLARGGSKGIP HHHHHHHCCCCCCCC	45.93	24129315
53	Phosphorylation	LVLARGGSKGIPLKN HHHHCCCCCCCCHHH	30.45	30482847
54	Ubiquitination	VLARGGSKGIPLKNI HHHCCCCCCCCHHHH	65.22	-
54	Malonylation	VLARGGSKGIPLKNI HHHCCCCCCCCHHHH	65.22	26320211
59	Ubiquitination	GSKGIPLKNIKRLAG CCCCCCHHHHHHHHC	51.80	22790023
59	Malonylation	GSKGIPLKNIKRLAG CCCCCCHHHHHHHHC	51.80	32601280
183	Ubiquitination	FRWSEIQKGVREVTE CCHHHHHHHHCCCCC	66.10	22790023
227	Phosphorylation	RHLIEMGYLQGGKMA EHHHHCCCCCCCEEE	8.44	26060331
304	Acetylation	EIISYDVKDAIGISL EEEEEEHHHHHHHHH	38.25	23954790
329	Ubiquitination	ISERACSKQTLSALK EEHHHCCHHHHHHHC	47.38	-
329	Malonylation	ISERACSKQTLSALK EEHHHCCHHHHHHHC	47.38	26320211
380	Ubiquitination	VSDEECLKRVGLSAV CCHHHHHHHHCCCCC	57.61	22790023
392	S-palmitoylation	SAVPADACSGAQKAV CCCCCHHCCCHHHHH	3.87	28526873
404	Malonylation	KAVGYICKCSGGRGA HHHHHHEECCCCCHH	23.13	26320211
404	Ubiquitination	KAVGYICKCSGGRGA HHHHHHEECCCCCHH	23.13	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NEUA_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NEUA_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NEUA_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NEUA_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.