NETO1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NETO1_HUMAN
• UniProt AC: Q8TDF5
• Protein Name: Neuropilin and tolloid-like protein 1
• Gene Name: NETO1
• Organism: Homo sapiens (Human).
• Sequence Length: 533
• Subcellular Localization: Isoform 2: Cell membrane ; Single-pass type I membrane protein . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Component of the postsynaptic density (PSD) of excitatory synapses..; Isoform 3: Cell membrane ; Single-pass ty
• Protein Description: Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory (By similarity)..
• Protein Sequence: MIHGRSVLHIVASLIILHLSGATKKGTEKQTTSETQKSVQCGTWTKHAEGGIFTSPNYPSKYPPDRECIYIIEAAPRQCIELYFDEKYSIEPSWECKFDHIEVRDGPFGFSPIIGRFCGQQNPPVIKSSGRFLWIKFFADGELESMGFSARYNFTPDPDFKDLGALKPLPACEFEMGGSEGIVESIQIMKEGKATASEAVDCKWYIRAPPRSKIYLRFLDYEMQNSNECKRNFVAVYDGSSSVEDLKAKFCSTVANDVMLRTGLGVIRMWADEGSRNSRFQMLFTSFQEPPCEGNTFFCHSNMCINNTLVCNGLQNCVYPWDENHCKEKRKTSLLDQLTNTSGTVIGVTSCIVIILIIISVIVQIKQPRKKYVQRKSDFDQTVFQEVFEPPHYELCTLRGTGATADFADVADDFENYHKLRRSSSKCIHDHHCGSQLSSTKGSRSNLSTRDASILTEMPTQPGKPLIPPMNRRNILVMKHSYSQDAADACDIDEIEEVPTTSHRLSRHDKAVQRFCLIGSLSKHESEYNTTRV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MIHGRSVLHIVAS --CCCCHHHHHHHHH	33.35	-
13	Phosphorylation	SVLHIVASLIILHLS HHHHHHHHHHHHHHC	14.81	-
20	Phosphorylation	SLIILHLSGATKKGT HHHHHHHCCCCCCCC	18.68	-
23	Phosphorylation	ILHLSGATKKGTEKQ HHHHCCCCCCCCCCC	36.49	-
31	Phosphorylation	KKGTEKQTTSETQKS CCCCCCCCCCCCHHH	43.27	29083192
32	Phosphorylation	KGTEKQTTSETQKSV CCCCCCCCCCCHHHE	23.28	29083192
33	Phosphorylation	GTEKQTTSETQKSVQ CCCCCCCCCCHHHEE	41.87	29083192
35	Phosphorylation	EKQTTSETQKSVQCG CCCCCCCCHHHEECC	40.85	29083192
38	Phosphorylation	TTSETQKSVQCGTWT CCCCCHHHEECCCCE	13.96	29083192
43	Phosphorylation	QKSVQCGTWTKHAEG HHHEECCCCEECCCC	37.27	29083192
45	Phosphorylation	SVQCGTWTKHAEGGI HEECCCCEECCCCCC	16.88	29083192
54	Phosphorylation	HAEGGIFTSPNYPSK CCCCCCCCCCCCCCC	41.16	28387310
58	Phosphorylation	GIFTSPNYPSKYPPD CCCCCCCCCCCCCCC	16.56	28387310
60	Phosphorylation	FTSPNYPSKYPPDRE CCCCCCCCCCCCCCC	34.17	28387310
128	Phosphorylation	QNPPVIKSSGRFLWI CCCCEEEECCCEEEE	27.22	24719451
237	Phosphorylation	KRNFVAVYDGSSSVE CCCEEEEEECCCCHH	12.59	-
240	Phosphorylation	FVAVYDGSSSVEDLK EEEEEECCCCHHHHH	19.28	-
306	N-linked_Glycosylation	CHSNMCINNTLVCNG ECCCEEECCEEEECC	30.42	UniProtKB CARBOHYD
340	N-linked_Glycosylation	SLLDQLTNTSGTVIG HHHHHHHCCCCCHHH	40.62	UniProtKB CARBOHYD
376	Methylation	RKKYVQRKSDFDQTV CHHHHCCHHHCCHHH	36.97	-
417	Phosphorylation	VADDFENYHKLRRSS HHHHHHHHHHHHHCC	7.98	-
460	O-linked_Glycosylation	SILTEMPTQPGKPLI HHHCCCCCCCCCCCC	46.19	29351928

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NETO1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NETO1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NETO1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of NETO1_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.