NEK8_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NEK8_MOUSE
• UniProt AC: Q91ZR4
• Protein Name: Serine/threonine-protein kinase Nek8
• Gene Name: Nek8
• Organism: Mus musculus (Mouse).
• Sequence Length: 698
• Subcellular Localization: Cytoplasm . Cytoplasm, cytoskeleton . Cell projection, cilium . Predominantly cytoplasmic. Localizes to the proximal region of the primary cilium and is not observed in dividing cells.
• Protein Description: Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia. Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway..
• Protein Sequence: MEKYERIRVVGRGAFGIVHLCLRKADQKLVILKQIPVEQMTKEERQAAQNECQVLKLLNHPNVIEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVHTHLILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSKAYTVVGTPCYISPELCEGKPYNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLSLEPAQRPPLSHIMAQPLCIRALLNIHTDVGSVRMRRAEKSLTPGPPIASGSTGSRATSARCRGVPRGPVRPAIPPPLSSVYAWGGGLSSPLRLPMLNTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGTLLPGAVELPQPQFVSRFLEGQSGVTIKHVACGDLFTACLTDRGIIMTFGSGSNGCLGHGNLTDISQPTIVEALLGYEMVQVACGASHVLALSTDGELFAWGRGDGGRLGLGTRESHNCPQQVPVAPGQEAQRVVCGIDSSMILTSPGRVLACGSNRFNKLGLDHLSLDEEPVPYQQVEEALSFTPLGSAPLDQEPLLCVDLGTAHSAAITASGDCYTFGSNQHGQLGTSSRRVSRAPCRVQGLEGIKMVMVACGDAFTVAVGAEGEVYSWGKGTRGRLGRRDEDAGLPRPVQLDETHPYMVTSVSCCHGNTLLAVRSVTDEPVPP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
162	Phosphorylation	SSKSKAYTVVGTPCY CCCCCCEEEECCCCC	17.36	-
217	Phosphorylation	ALVLKIMSGTFAPIS HHHHHHHHCCCCCCH	37.85	28059163
224	Phosphorylation	SGTFAPISDRYSPEL HCCCCCCHHHCCHHH	18.25	28059163
280	Phosphorylation	RMRRAEKSLTPGPPI HHHCCHHCCCCCCCC	29.04	26239621
282	Phosphorylation	RRAEKSLTPGPPIAS HCCHHCCCCCCCCCC	33.03	26239621
318	Phosphorylation	PAIPPPLSSVYAWGG CCCCCCCCCEEEECC	24.43	29899451
319	Phosphorylation	AIPPPLSSVYAWGGG CCCCCCCCEEEECCC	27.16	29899451
328	Phosphorylation	YAWGGGLSSPLRLPM EEECCCCCCCCCCCC	32.93	29899451
329	Phosphorylation	AWGGGLSSPLRLPML EECCCCCCCCCCCCC	32.75	29899451
518	Phosphorylation	DSSMILTSPGRVLAC CHHHEEECCCCEEEE	23.16	28059163

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NEK8_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NEK8_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NEK8_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NEK8_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.