NEDD8_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NEDD8_RAT
• UniProt AC: Q71UE8
• Protein Name: NEDD8
• Gene Name: Nedd8
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 81
• Subcellular Localization: Nucleus. Mainly nuclear..
• Protein Description: Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity)..
• Protein Sequence: MLIKVKTLTGKEIEIDIEPTDKVERIKERVEEKEGIPPQQQRLIYSGKQMNDEKTAADYKILGGSVLHLVLALRGGGGLGQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Acetylation	----MLIKVKTLTGK ----CEEEEEECCCC	33.45	22902405
11	Acetylation	KVKTLTGKEIEIDIE EEEECCCCEEEEECC	50.73	22902405
11	Ubiquitination	KVKTLTGKEIEIDIE EEEECCCCEEEEECC	50.73	-
22	Acetylation	IDIEPTDKVERIKER EECCCCHHHHHHHHH	48.77	22902405
22	Ubiquitination	IDIEPTDKVERIKER EECCCCHHHHHHHHH	48.77	-
27	Ubiquitination	TDKVERIKERVEEKE CHHHHHHHHHHHHHC	45.77	-
48	Acetylation	QRLIYSGKQMNDEKT HHEEEECCCCCCCCC	40.20	22902405
48	Ubiquitination	QRLIYSGKQMNDEKT HHEEEECCCCCCCCC	40.20	-
54	Acetylation	GKQMNDEKTAADYKI CCCCCCCCCHHHHEE	46.45	22902405
54	Ubiquitination	GKQMNDEKTAADYKI CCCCCCCCCHHHHEE	46.45	-
65	Phosphorylation	DYKILGGSVLHLVLA HHEEHHHHHHHHHHH	21.51	23984901

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NEDD8_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NEDD8_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NEDD8_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of NEDD8_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.