NDUV1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDUV1_MOUSE
• UniProt AC: Q91YT0
• Protein Name: NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
• Gene Name: Ndufv1
• Organism: Mus musculus (Mouse).
• Sequence Length: 464
• Subcellular Localization: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
• Protein Description: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)..
• Protein Sequence: MLAARHFLGGLVPVRVSVRFSSGTTAPKKTSFGSLKDEDRIFTNLYGRHDWRLKGALRRGDWYKTKEILLKGPDWILGEMKTSGLRGRGGAGFPTGLKWSFMNKPSDGRPKYLVVNADEGEPGTCKDREIMRHDPHKLVEGCLVGGRAMGARAAYIYIRGEFYNEASNLQVAIREAYEAGLIGKNACGSDYDFDVFVVRGAGAYICGEETALIESIEGKQGKPRLKPPFPADVGVFGCPTTVANVETVAVSPTICRRGGTWFAGFGRERNSGTKLFNISGHVNHPCTVEEEMSVPLKELIEKHAGGVTGGWDNLLAVIPGGSSTPLIPKSVCETVLMDFDALVQAQTGLGTAAVIVMDRSTDIVKAIARLIEFYKHESCGQCTPCREGVDWMNKVMARFVKGDARPAEIDSLWEISKQIEGHTICALGDGAAWPVQGLIRHFRPELEDRMQRFAQQHRAWQAAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	Phosphorylation	GTTAPKKTSFGSLKD CCCCCCCCCCCCCCC	35.10	27742792
31	Phosphorylation	TTAPKKTSFGSLKDE CCCCCCCCCCCCCCC	36.17	27742792
34	Phosphorylation	PKKTSFGSLKDEDRI CCCCCCCCCCCCCCE	30.18	23737553
36	Acetylation	KTSFGSLKDEDRIFT CCCCCCCCCCCCEEH	61.85	23864654
36	Succinylation	KTSFGSLKDEDRIFT CCCCCCCCCCCCEEH	61.85	26388266
54	Acetylation	GRHDWRLKGALRRGD CCCCHHHCCHHHCCC	33.30	24062335
64	Acetylation	LRRGDWYKTKEILLK HHCCCCCEEEEHHCC	49.19	23864654
66	Succinylation	RGDWYKTKEILLKGP CCCCCEEEEHHCCCC	38.31	26388266
66	Acetylation	RGDWYKTKEILLKGP CCCCCEEEEHHCCCC	38.31	24062335
81	Succinylation	DWILGEMKTSGLRGR CEECCCCCCCCCCCC	34.93	23806337
81	Acetylation	DWILGEMKTSGLRGR CEECCCCCCCCCCCC	34.93	23576753
81	Succinylation	DWILGEMKTSGLRGR CEECCCCCCCCCCCC	34.93	-
104	Succinylation	LKWSFMNKPSDGRPK CCEEECCCCCCCCCC	33.83	24315375
104	Acetylation	LKWSFMNKPSDGRPK CCEEECCCCCCCCCC	33.83	23576753
125	S-nitrosylation	DEGEPGTCKDREIMR CCCCCCCCCCHHHHH	5.52	21278135
125	S-palmitoylation	DEGEPGTCKDREIMR CCCCCCCCCCHHHHH	5.52	28526873
125	S-nitrosocysteine	DEGEPGTCKDREIMR CCCCCCCCCCHHHHH	5.52	-
137	Acetylation	IMRHDPHKLVEGCLV HHHCCHHHHCCCCEE	60.66	24062335
142	S-nitrosocysteine	PHKLVEGCLVGGRAM HHHHCCCCEECCHHH	1.44	-
142	S-palmitoylation	PHKLVEGCLVGGRAM HHHHCCCCEECCHHH	1.44	28526873
142	S-nitrosylation	PHKLVEGCLVGGRAM HHHHCCCCEECCHHH	1.44	22588120
163	Phosphorylation	IYIRGEFYNEASNLQ EEECCCCCCCCCCHH	14.06	-
167	Phosphorylation	GEFYNEASNLQVAIR CCCCCCCCCHHHHHH	31.71	-
177	Phosphorylation	QVAIREAYEAGLIGK HHHHHHHHHCCCCCC	11.10	-
187	S-nitrosylation	GLIGKNACGSDYDFD CCCCCCCCCCCCCEE	8.19	24895380
187	S-nitrosocysteine	GLIGKNACGSDYDFD CCCCCCCCCCCCCEE	8.19	-
187	S-palmitoylation	GLIGKNACGSDYDFD CCCCCCCCCCCCCEE	8.19	28526873
206	S-nitrosocysteine	RGAGAYICGEETALI ECCCEEECCCCEEEE	3.50	-
206	S-palmitoylation	RGAGAYICGEETALI ECCCEEECCCCEEEE	3.50	28526873
206	S-nitrosylation	RGAGAYICGEETALI ECCCEEECCCCEEEE	3.50	24895380
226	Acetylation	KQGKPRLKPPFPADV CCCCCCCCCCCCCCE	52.50	23864654
238	S-palmitoylation	ADVGVFGCPTTVANV CCEEEECCCCCEECC	1.51	28526873
238	S-nitrosylation	ADVGVFGCPTTVANV CCEEEECCCCCEECC	1.51	24895380
255	S-palmitoylation	VAVSPTICRRGGTWF EEECCEEECCCCCEE	2.39	28526873
255	S-nitrosylation	VAVSPTICRRGGTWF EEECCEEECCCCCEE	2.39	24895380
257	Methylation	VSPTICRRGGTWFAG ECCEEECCCCCEEEE	43.40	24129315
286	S-nitrosylation	SGHVNHPCTVEEEMS ECCCCCCCCCCCHHC	5.31	21278135
286	S-nitrosocysteine	SGHVNHPCTVEEEMS ECCCCCCCCCCCHHC	5.31	-
308	Phosphorylation	EKHAGGVTGGWDNLL HHHCCCCCCCHHHEE	33.00	-
365	Succinylation	DRSTDIVKAIARLIE ECCHHHHHHHHHHHH	34.12	23954790
365	Acetylation	DRSTDIVKAIARLIE ECCHHHHHHHHHHHH	34.12	23864654
375	Acetylation	ARLIEFYKHESCGQC HHHHHHHHHCCCCCC	46.33	23576753
394	Acetylation	EGVDWMNKVMARFVK HCHHHHHHHHHHHHC	19.79	23864654
401	Acetylation	KVMARFVKGDARPAE HHHHHHHCCCCCCHH	48.65	24062335
401	Succinylation	KVMARFVKGDARPAE HHHHHHHCCCCCCHH	48.65	26388266
425	Glutathionylation	QIEGHTICALGDGAA HHCCCEEEECCCCHH	2.41	24333276
425	S-nitrosylation	QIEGHTICALGDGAA HHCCCEEEECCCCHH	2.41	21278135
425	S-palmitoylation	QIEGHTICALGDGAA HHCCCEEEECCCCHH	2.41	28526873
425	S-nitrosocysteine	QIEGHTICALGDGAA HHCCCEEEECCCCHH	2.41	-
464	Phosphorylation	HRAWQAAS------- HHHHHHCC-------	43.71	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NDUV1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NDUV1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDUV1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NDUV1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Substrate and functional diversity of lysine acetylation revealed bya proteomics survey.";
Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T.,Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.;
Mol. Cell 23:607-618(2006).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-81; LYS-104 AND LYS-375, ANDMASS SPECTROMETRY.
PubMed: 16916647