NDUS8_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDUS8_MOUSE
• UniProt AC: Q8K3J1
• Protein Name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
• Gene Name: Ndufs8
• Organism: Mus musculus (Mouse).
• Sequence Length: 212
• Subcellular Localization: Mitochondrion.
• Protein Description: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)..
• Protein Sequence: MYRLSSSMLPRALAQAMRTGHLNGQSLHSSAVAATYKYVNKKEQESEVDMKSATDNAARILMWTELIRGLGMTLSYLFREPATINYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAICPAQAITIEAEPRADGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEFSTETHEELLYNKEKLLNNGDKWEAEIAANIQADYLYR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MYRLSSSML ------CCCCCCCHH	21.91	17203969
5	Phosphorylation	---MYRLSSSMLPRA ---CCCCCCCHHHHH	16.03	17203969
6	Phosphorylation	--MYRLSSSMLPRAL --CCCCCCCHHHHHH	25.10	17203969
7	Phosphorylation	-MYRLSSSMLPRALA -CCCCCCCHHHHHHH	22.44	28059163
41	Acetylation	ATYKYVNKKEQESEV HHHHHCCHHHHHCCC	47.87	24062335
42	Acetylation	TYKYVNKKEQESEVD HHHHCCHHHHHCCCC	60.47	24062335
46	Phosphorylation	VNKKEQESEVDMKSA CCHHHHHCCCCHHHH	42.48	25159016
51	Acetylation	QESEVDMKSATDNAA HHCCCCHHHHHHHHH	32.26	23864654
51	Succinylation	QESEVDMKSATDNAA HHCCCCHHHHHHHHH	32.26	26388266
54	Phosphorylation	EVDMKSATDNAARIL CCCHHHHHHHHHHHH	36.56	28576409
94	Phosphorylation	PFEKGPLSPRFRGEH CCCCCCCCCCCCCHH	19.70	24719451
108	Phosphorylation	HALRRYPSGEERCIA HHHHHCCCCCCCHHH	50.32	23737553
119	Glutathionylation	RCIACKLCEAICPAQ CHHHHHHHHHHCCCC	1.71	24333276
119	S-nitrosylation	RCIACKLCEAICPAQ CHHHHHHHHHHCCCC	1.71	24895380
119	S-palmitoylation	RCIACKLCEAICPAQ CHHHHHHHHHHCCCC	1.71	28526873
123	Glutathionylation	CKLCEAICPAQAITI HHHHHHHCCCCCEEE	2.70	24333276
123	S-nitrosylation	CKLCEAICPAQAITI HHHHHHHCCCCCEEE	2.70	24895380
123	S-palmitoylation	CKLCEAICPAQAITI HHHHHHHCCCCCEEE	2.70	28526873
150	O-linked_Glycosylation	TRYDIDMTKCIYCGF CEEEECCCCEEECCC	21.00	55414505

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NDUS8_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NDUS8_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDUS8_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NDUS8_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.