NDUS7_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDUS7_MOUSE
• UniProt AC: Q9DC70
• Protein Name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
• Gene Name: Ndufs7
• Organism: Mus musculus (Mouse).
• Sequence Length: 224
• Subcellular Localization: Mitochondrion .
• Protein Description: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone..
• Protein Sequence: MAALAAPGLLSVRILGLRTAQVQLRRVHQSVATEGPSPSPSPSLSSTQSAVSKAGAGAVVPKLSHLPRSRAEYVVTKLDDLINWARRSSLWPMTFGLACCAVEMMHMAAPRYDMDRFGVVFRASPRQADVMIVAGTLTNKMAPALRKVYDQMPEPRYVVSMGSCANGGGYYHYSYSVVRGCDRIVPVDIYVPGCPPTAEALLYGILQLQRKIKREQKLKIWYRR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Phosphorylation	RVHQSVATEGPSPSP HHHHHHCCCCCCCCC	39.04	25619855
37	Phosphorylation	SVATEGPSPSPSPSL HHCCCCCCCCCCCCC	49.19	25619855
39	Phosphorylation	ATEGPSPSPSPSLSS CCCCCCCCCCCCCCH	42.20	27742792
41	Phosphorylation	EGPSPSPSPSLSSTQ CCCCCCCCCCCCHHH	31.30	25619855
43	Phosphorylation	PSPSPSPSLSSTQSA CCCCCCCCCCHHHHH	45.26	25619855
45	Phosphorylation	PSPSPSLSSTQSAVS CCCCCCCCHHHHHHH	35.36	25619855
47	Phosphorylation	PSPSLSSTQSAVSKA CCCCCCHHHHHHHHH	24.14	25619855
62	Acetylation	GAGAVVPKLSHLPRS CCCCCCCCHHCCCHH	51.52	24062335
73	Phosphorylation	LPRSRAEYVVTKLDD CCHHHHEHHEECHHH	10.15	25195567
77	Acetylation	RAEYVVTKLDDLINW HHEHHEECHHHHHHH	38.01	23954790
136	Phosphorylation	DVMIVAGTLTNKMAP CEEEEECCCCCCHHH	22.22	-
138	Phosphorylation	MIVAGTLTNKMAPAL EEEECCCCCCHHHHH	32.41	-
164	S-nitrosocysteine	YVVSMGSCANGGGYY EEEEECCCCCCCCCC	2.56	-
164	S-nitrosylation	YVVSMGSCANGGGYY EEEEECCCCCCCCCC	2.56	21278135
194	Glutathionylation	VDIYVPGCPPTAEAL EEEECCCCCCHHHHH	2.74	24333276
194	S-palmitoylation	VDIYVPGCPPTAEAL EEEECCCCCCHHHHH	2.74	28526873

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NDUS7_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
111	R	Hydroxylation	Hydroxylated ar Arg-111 by NDUFAF5 early in the pathway of assembly of complex I, before the formation of the juncture between peripheral and membrane arms.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDUS7_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NDUS7_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.