NDUS4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDUS4_MOUSE
• UniProt AC: Q9CXZ1
• Protein Name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
• Gene Name: Ndufs4
• Organism: Mus musculus (Mouse).
• Sequence Length: 175
• Subcellular Localization: Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side .
• Protein Description: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone..
• Protein Sequence: MAAVSISVSLRQAMLGRRAMATAAVSVCRVPSRLLSTSTWKLADNQTRDTQLITVDEKLDITTLTGVPEEHIKTRKVRIFVPARNNMQSGVNNTKKWKMEFDTRERWENPLMGWASTADPLSNMVLTFSAKEDAIAFAEKNGWSYDVEEKKVPKPKSKSYGANFSWNKRTRVSTK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MAAVSISVSLRQAM -CCCEEEEHHHHHHH	9.72	30387612
9	Phosphorylation	AAVSISVSLRQAMLG CCEEEEHHHHHHHHH	15.84	22802335
73	Ubiquitination	GVPEEHIKTRKVRIF CCCHHHCCCCEEEEE	44.15	-
95	Acetylation	QSGVNNTKKWKMEFD CCCCCCCCCEEEEEC	59.78	160929
95	Succinylation	QSGVNNTKKWKMEFD CCCCCCCCCEEEEEC	59.78	26388266
96	Succinylation	SGVNNTKKWKMEFDT CCCCCCCCEEEEECC	50.43	26388266
98	Succinylation	VNNTKKWKMEFDTRE CCCCCCEEEEECCHH	37.11	26388266
144	Phosphorylation	FAEKNGWSYDVEEKK HHHHHCCCCCCCCCC	16.92	19060867
150	Acetylation	WSYDVEEKKVPKPKS CCCCCCCCCCCCCCC	45.63	23864654
150	Succinylation	WSYDVEEKKVPKPKS CCCCCCCCCCCCCCC	45.63	23954790
154	Acetylation	VEEKKVPKPKSKSYG CCCCCCCCCCCCCCC	68.98	23201123
168	Acetylation	GANFSWNKRTRVSTK CCCCCCCCCCCCCCC	49.22	2394853
168	Succinylation	GANFSWNKRTRVSTK CCCCCCCCCCCCCCC	49.22	23954790
173	Phosphorylation	WNKRTRVSTK----- CCCCCCCCCC-----	27.47	20433953

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NDUS4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NDUS4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDUS4_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NDUS4_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.