NDUS2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDUS2_MOUSE
• UniProt AC: Q91WD5
• Protein Name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
• Gene Name: Ndufs2
• Organism: Mus musculus (Mouse).
• Sequence Length: 463
• Subcellular Localization: Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side .
• Protein Description: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone..
• Protein Sequence: MAALRALRCLRGVGAPVLRPGSGIRLPSQPSRGARQWQPDIEWAEQFSGAVMYPSKETAHWKPPPWNDVDILKEKAVTNMTLNFGPQHPAAHGVLRLVLELSGEMVRKCDPHIGLLHRGTEKLIEYKTYLQALPYFDRLDYVSMMCNEQAYSIAVEKLLNIQPPPRAQWIRVLFGEITRILNHIMAVTTHALDIGAMTPFFWMFEEREKMFEFYERVSGARMHAAYIRPGGVHQDLPLGLLDDIYEFSKNFSLRIDEVEEMLTNNRIWRNRTVDIGVVTAEDALNYGFSGVMLRGSGIQWDLRKTQPYDVYDQVEFDVPIGSRGDCYDRYLCRVEEMRQSLRIIEQCLNKMPPGEIKVDDAKVSPPKRAEMKTSMESLIHHFKLYTEGYQVPPGATYTAIEAPKGEFGVYLVSDGSSRPYRCKIKAPGFAHLAGLDKMSKGHMLADVVAIIGTQDIVFGEIDR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
62	Acetylation	SKETAHWKPPPWNDV CCCCCCCCCCCCCCC	37.47	23576753
62	Succinylation	SKETAHWKPPPWNDV CCCCCCCCCCCCCCC	37.47	23954790
118	Symmetric dimethylarginine	PHIGLLHRGTEKLIE CCCEECCCCHHHHHH	54.41	-
118	Methylation	PHIGLLHRGTEKLIE CCCEECCCCHHHHHH	54.41	-
146	S-nitrosocysteine	LDYVSMMCNEQAYSI CHHHHHHCCHHHHHH	3.67	-
146	S-nitrosylation	LDYVSMMCNEQAYSI CHHHHHHCCHHHHHH	3.67	21278135
272	Phosphorylation	NRIWRNRTVDIGVVT CCCCCCCEEEEEEEE	26.53	26643407
279	Phosphorylation	TVDIGVVTAEDALNY EEEEEEEEHHHHHHC	23.17	26643407
286	Phosphorylation	TAEDALNYGFSGVML EHHHHHHCCCCEEEE	22.01	26643407
289	Phosphorylation	DALNYGFSGVMLRGS HHHHCCCCEEEEECC	26.56	26643407
304	Ubiquitination	GIQWDLRKTQPYDVY CCCCCCCCCCCCCEE	59.83	22790023
347	S-palmitoylation	SLRIIEQCLNKMPPG HHHHHHHHHHCCCCC	2.68	28526873
350	Acetylation	IIEQCLNKMPPGEIK HHHHHHHCCCCCCCE	39.57	23864654
374	Phosphorylation	KRAEMKTSMESLIHH CHHHHHHHHHHHHHH	18.29	27742792
437	Acetylation	AHLAGLDKMSKGHML HHHCCCCCCCCCCCH	50.55	23201123

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NDUS2_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
118	R	Methylation	Dimethylation at Arg-118 by NDUFAF7 takes place after NDUFS2 assembles into the complex I, leading to stabilize the early intermediate complex.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDUS2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NDUS2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.