NDUS1_RAT - dbPTM
NDUS1_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NDUS1_RAT
UniProt AC Q66HF1
Protein Name NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Gene Name Ndufs1
Organism Rattus norvegicus (Rat).
Sequence Length 727
Subcellular Localization Mitochondrion inner membrane. Matrix and cytoplasmic side of the mitochondrial inner membrane..
Protein Description Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized (By similarity)..
Protein Sequence MLRIPVKRALIGLSKSPKGYVRSTGTAASNLIEVFVDGQSVMVEPGTTVLQACEKVGMQIPRFCYHERLSVAGNCRMCLVEIEKAPKVVAACAMPVMKGWNILTNSEKSKKAREGVMEFLLANHPLDCPICDQGGECDLQDQSMMFGSDRSRFLEGKRAVEDKNIGPLVKTIMTRCIQCTRCIRFASEIAGVDDLGTTGRGNDMQVGTYIEKMFMSELSGNIIDICPVGALTSKPYAFTARPWETRKTESIDVMDAVGSNIVVSTRTGEVMRILPRMHEDINEEWISDKTRFAYDGLKRQRLTEPMVRNEKGLLTYTSWEDALSRVAGMLQSFEGKAVAAIAGGLVDAEALVALKDLLNKVDSDTLCTEEIFPNEGAGTDLRSNYLLNTTIAGVEEADVVLLVGTNPRFEAPLFNARIRKSWLHNDLKVALIGSPVDLTYRYDHLGDSPKILQDIASGNHEFSKVLNAAKKPMVVLGSSALQRDDGAAILAAVSSIAQKIRVASGAAAEWKVMNILHRIASQVAALDLGYKPGVEAIRKNPPKLLFLLGADGGCITRQDLPKDCFIVYQGHHGDVGAPIADVILPGAAYTEKSATYVNTEGRAQQTKVAVTPPGLAREDWKIIRALSEIAGITLPYDTLDQVRNRLGEVSPNLVRYDDVEEANYFQQASELAKLVDQEFLADPLVPPQLTIKDFYMTDSISRASQTMAKCVKAVTEGAQAVEEPSIC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
84AcetylationMCLVEIEKAPKVVAA
EEEEEHHHCCHHHHH		75.5422902405
87AcetylationVEIEKAPKVVAACAM
EEHHHCCHHHHHHHC		54.9526302492
163AcetylationGKRAVEDKNIGPLVK
CCHHHCCCCHHHHHH		36.6422902405
170AcetylationKNIGPLVKTIMTRCI
CCHHHHHHHHHHHHH		39.7622902405
187O-linked_GlycosylationTRCIRFASEIAGVDD
HHHHHHHHHHHCCCC		27.1627213235
248PhosphorylationRPWETRKTESIDVMD
CCCCCCCCCCCEEEH		31.5125575281
250PhosphorylationWETRKTESIDVMDAV
CCCCCCCCCEEEHHC		29.3525575281
259PhosphorylationDVMDAVGSNIVVSTR
EEEHHCCCCEEEECC		19.4525575281
264PhosphorylationVGSNIVVSTRTGEVM
CCCCEEEECCCHHHH		10.9825575281
265PhosphorylationGSNIVVSTRTGEVMR
CCCEEEECCCHHHHH		22.2025575281
287O-linked_GlycosylationDINEEWISDKTRFAY
CCCHHHHCCCHHHCC		33.8427213235
294PhosphorylationSDKTRFAYDGLKRQR
CCCHHHCCCCHHHCC		14.0824259510
298AcetylationRFAYDGLKRQRLTEP
HHCCCCHHHCCCCCC		52.6022902405
311AcetylationEPMVRNEKGLLTYTS
CCCCCCCCCCEEECC		59.4122902405
316PhosphorylationNEKGLLTYTSWEDAL
CCCCCEEECCHHHHH		9.95-
318O-linked_GlycosylationKGLLTYTSWEDALSR
CCCEEECCHHHHHHH		20.3227213235
448PhosphorylationRYDHLGDSPKILQDI
ECCCCCCCHHHHHHH		26.7123991683
450AcetylationDHLGDSPKILQDIAS
CCCCCCHHHHHHHHC		61.0622902405
464AcetylationSGNHEFSKVLNAAKK
CCCHHHHHHHHHCCC		56.9422902405
470AcetylationSKVLNAAKKPMVVLG
HHHHHHCCCCEEEEC		55.8126302492
478O-linked_GlycosylationKPMVVLGSSALQRDD
CCEEEECCCCCCCCC		14.3127213235
494O-linked_GlycosylationAAILAAVSSIAQKIR
HHHHHHHHHHHHHHH		15.9927213235
495PhosphorylationAILAAVSSIAQKIRV
HHHHHHHHHHHHHHH		18.4916641100
499AcetylationAVSSIAQKIRVASGA
HHHHHHHHHHHHCCC		24.3722902405
504O-linked_GlycosylationAQKIRVASGAAAEWK
HHHHHHHCCCHHHHH		26.5527213235
511AcetylationSGAAAEWKVMNILHR
CCCHHHHHHHHHHHH		24.1022902405
521O-linked_GlycosylationNILHRIASQVAALDL
HHHHHHHHHHHHHHC		23.8627213235
539AcetylationPGVEAIRKNPPKLLF
CCHHHHHHCCCCEEE		68.6326302492
543AcetylationAIRKNPPKLLFLLGA
HHHHCCCCEEEEECC		60.1122902405
562AcetylationITRQDLPKDCFIVYQ
ECCCCCCCCEEEEEC		74.5422902405
592AcetylationPGAAYTEKSATYVNT
CCCCCCCCCEEEECC		37.2826302492
621AcetylationGLAREDWKIIRALSE
CHHHHHHHHHHHHHH		40.3522902405
627O-linked_GlycosylationWKIIRALSEIAGITL
HHHHHHHHHHHCCCC		26.4427213235
709AcetylationRASQTMAKCVKAVTE
HHHHHHHHHHHHHHH		28.83-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NDUS1_RAT !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NDUS1_RAT !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NDUS1_RAT !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of NDUS1_RAT !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NDUS1_RAT

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Related Literatures of Post-Translational Modification

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