NDUAC_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDUAC_MOUSE
• UniProt AC: Q7TMF3
• Protein Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
• Gene Name: Ndufa12
• Organism: Mus musculus (Mouse).
• Sequence Length: 145
• Subcellular Localization: Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side .
• Protein Description: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone..
• Protein Sequence: MELVEVLKRGVQQVTGHGGLRGLLRVFFRANDIRIGTLVGEDKYGNKYYEDNKQFFGRHRWVIYTTEMNGKNTFWDVDGSMVPPEWHRWLHCMTDDPPTTNPPTARKFIWTNHKFNVSATPEQYVPYSTTRKKIHEWVPPSTPYK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MELVEVLK -------CCHHHHHH	8.96	-
8	Acetylation	MELVEVLKRGVQQVT CCHHHHHHHHHHHHH	52.89	23954790
43	Acetylation	GTLVGEDKYGNKYYE EEEEEECCCCCEEEE	51.24	23864654
47	Acetylation	GEDKYGNKYYEDNKQ EECCCCCEEEECCCE	44.86	23864654
53	Acetylation	NKYYEDNKQFFGRHR CEEEECCCEEECCCC	61.88	23201123
53	Succinylation	NKYYEDNKQFFGRHR CEEEECCCEEECCCC	61.88	26388266
92	S-nitrosocysteine	EWHRWLHCMTDDPPT HHHCCHHCCCCCCCC	2.69	-
92	S-nitrosylation	EWHRWLHCMTDDPPT HHHCCHHCCCCCCCC	2.69	21278135
92	S-palmitoylation	EWHRWLHCMTDDPPT HHHCCHHCCCCCCCC	2.69	28526873
104	Phosphorylation	PPTTNPPTARKFIWT CCCCCCCCCHHEEEE	40.11	-
141	Phosphorylation	IHEWVPPSTPYK--- HHHCCCCCCCCC---	35.62	23140645
142	Phosphorylation	HEWVPPSTPYK---- HHCCCCCCCCC----	36.09	23140645
145	Acetylation	VPPSTPYK------- CCCCCCCC-------	55.88	2393727
145	Succinylation	VPPSTPYK------- CCCCCCCC-------	55.88	26388266

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NDUAC_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NDUAC_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDUAC_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NDUAC_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Substrate and functional diversity of lysine acetylation revealed bya proteomics survey.";
Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T.,Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.;
Mol. Cell 23:607-618(2006).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-43 AND LYS-47, AND MASSSPECTROMETRY.
PubMed: 16916647