dbPTM

NDUAA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NDUAA_MOUSE
UniProt AC	Q99LC3
Protein Name	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
Gene Name	Ndufa10
Organism	Mus musculus (Mouse).
Sequence Length	355
Subcellular Localization	Mitochondrion matrix .
Protein Description	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone..
Protein Sequence	MALRLLRLVPASAPARGLAAGAQRVGRIHTSVHCKLRYGLLAAILGDKTTKKLHEYSRVITVDGNICSGKNKLAKEIAQQLGMKHYPEAGIQYSSTTTGDGRPLDIEFSGSCSLEKFYDDPKSNDGNSYRLQSWLYASRLLQYADALEHLLSTGQGVVLERSIYSDFVFLEAMYNQGYIRKQCVDHYNEIKRLTLPEYLPPHAVIYIDVPVPEVQSRIQKKGDPHEMKVTSAYLQDIENAYKKTFLPKMSEMCEVLVYDSWEAEDPTKVVEDIEYLKYNKGPWLKQDDWTFHYLRMLVQDKTEVLNYTTIPVYLPEITIGAHQGSRIYNSFRELPGRKYAPGYNAEVGDKWIWLK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
67	S-nitrosocysteine	ITVDGNICSGKNKLA EEECCCCCCCCHHHH	5.21	-
67	S-palmitoylation	ITVDGNICSGKNKLA EEECCCCCCCCHHHH	5.21	28526873
67	S-nitrosylation	ITVDGNICSGKNKLA EEECCCCCCCCHHHH	5.21	22588120
72	Acetylation	NICSGKNKLAKEIAQ CCCCCCHHHHHHHHH	53.99	24062335
75	Acetylation	SGKNKLAKEIAQQLG CCCHHHHHHHHHHHC	61.15	24062335
75	Succinylation	SGKNKLAKEIAQQLG CCCHHHHHHHHHHHC	61.15	26388266
84	Acetylation	IAQQLGMKHYPEAGI HHHHHCCCCCCCCCE	37.88	24062335
112	S-nitrosocysteine	DIEFSGSCSLEKFYD EEEEECCEEEEEECC	6.50	-
112	S-nitrosylation	DIEFSGSCSLEKFYD EEEEECCEEEEEECC	6.50	21278135
122	Acetylation	EKFYDDPKSNDGNSY EEECCCCCCCCCCCH	69.73	23576753
122	Succinylation	EKFYDDPKSNDGNSY EEECCCCCCCCCCCH	69.73	-
122	Ubiquitination	EKFYDDPKSNDGNSY EEECCCCCCCCCCCH	69.73	-
122	Succinylation	EKFYDDPKSNDGNSY EEECCCCCCCCCCCH	69.73	23806337
181	Acetylation	YNQGYIRKQCVDHYN HHCCCCHHHHHHCHH	38.19	16916647
183	S-nitrosocysteine	QGYIRKQCVDHYNEI CCCCHHHHHHCHHHH	4.33	-
183	S-nitrosylation	QGYIRKQCVDHYNEI CCCCHHHHHHCHHHH	4.33	21278135
191	Acetylation	VDHYNEIKRLTLPEY HHCHHHHHHCCCCCC	34.87	23864654
228	Acetylation	KGDPHEMKVTSAYLQ CCCHHHHHCCHHHHH	39.10	24062335
230	Phosphorylation	DPHEMKVTSAYLQDI CHHHHHCCHHHHHHH	11.34	29899451
231	Phosphorylation	PHEMKVTSAYLQDIE HHHHHCCHHHHHHHH	20.22	20495213
233	Phosphorylation	EMKVTSAYLQDIENA HHHCCHHHHHHHHHH	12.50	29899451
242	Succinylation	QDIENAYKKTFLPKM HHHHHHHHHHCHHHH	42.82	26388266
242	Acetylation	QDIENAYKKTFLPKM HHHHHHHHHHCHHHH	42.82	23864654
243	Succinylation	DIENAYKKTFLPKMS HHHHHHHHHCHHHHH	31.65	26388266
243	Acetylation	DIENAYKKTFLPKMS HHHHHHHHHCHHHHH	31.65	130453
250	Phosphorylation	KTFLPKMSEMCEVLV HHCHHHHHHCCEEEE	28.45	24652937
277	Succinylation	VEDIEYLKYNKGPWL EEEHHHHEECCCCCC	45.97	23954790
277	Acetylation	VEDIEYLKYNKGPWL EEEHHHHEECCCCCC	45.97	23864654
277	Ubiquitination	VEDIEYLKYNKGPWL EEEHHHHEECCCCCC	45.97	-
285	Succinylation	YNKGPWLKQDDWTFH ECCCCCCCCCCHHHH	48.05	-
285	Succinylation	YNKGPWLKQDDWTFH ECCCCCCCCCCHHHH	48.05	23806337
285	Acetylation	YNKGPWLKQDDWTFH ECCCCCCCCCCHHHH	48.05	23806337
318	Phosphorylation	PVYLPEITIGAHQGS CEECCEEEEECCCCC	16.23	-
325	Phosphorylation	TIGAHQGSRIYNSFR EEECCCCCHHHHCHH	14.66	-
338	Ubiquitination	FRELPGRKYAPGYNA HHCCCCCCCCCCCCC	52.24	27667366
350	Succinylation	YNAEVGDKWIWLK-- CCCCCCCEEEEEC--	34.35	23806337
350	Acetylation	YNAEVGDKWIWLK-- CCCCCCCEEEEEC--	34.35	16916647

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
250	S	Phosphorylation	Kinase	PINK1	Q99MQ3	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
242	K	Acetylation	-
Acetylation of Lys-242 is observed in liver mitochondria from fasted mice but not from fed mice.
250	S	Phosphorylation	24652937
Phosphorylation at Ser-250 by PINK1 is required for the binding and/or reduction of the complex I substrate ubiquinone.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NDUAA_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of NDUAA_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NDUAA_MOUSE

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Substrate and functional diversity of lysine acetylation revealed bya proteomics survey."; Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T.,Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.; Mol. Cell 23:607-618(2006). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-122; LYS-181; LYS-242 ANDLYS-350, AND MASS SPECTROMETRY.	16916647 [Abstract]

show

show