dbPTM

NDUA5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NDUA5_MOUSE
UniProt AC	Q9CPP6
Protein Name	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
Gene Name	Ndufa5
Organism	Mus musculus (Mouse).
Sequence Length	116
Subcellular Localization	Mitochondrion inner membrane Peripheral membrane protein Matrix side .
Protein Description	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone..
Protein Sequence	MAGLLKKTTGLVGLAVCDTPHERLTILYTKTLDILKHFPKHAAYRKYTEQITNEKLDMVKAEPDVKKLEALLQGGEVEEVILQAEKELSLARKMLKWKPWEPLVEEPPANQWKWPI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGLLKKTT ------CCCCCHHCC	19.83	-
17	S-nitrosocysteine	GLVGLAVCDTPHERL CEEEEEECCCCCHHE	3.92	-
17	S-palmitoylation	GLVGLAVCDTPHERL CEEEEEECCCCCHHE	3.92	28526873
17	S-nitrosylation	GLVGLAVCDTPHERL CEEEEEECCCCCHHE	3.92	21278135
30	Acetylation	RLTILYTKTLDILKH HEEEEEHHHHHHHHH	33.27	24062335
30	Succinylation	RLTILYTKTLDILKH HEEEEEHHHHHHHHH	33.27	26388266
36	Succinylation	TKTLDILKHFPKHAA HHHHHHHHHCCCCHH	43.46	23954790
36	Acetylation	TKTLDILKHFPKHAA HHHHHHHHHCCCCHH	43.46	23576753
40	Succinylation	DILKHFPKHAAYRKY HHHHHCCCCHHHHHH	44.95	23806337
40	Acetylation	DILKHFPKHAAYRKY HHHHHCCCCHHHHHH	44.95	23864654
46	Malonylation	PKHAAYRKYTEQITN CCCHHHHHHHHHHHH	43.79	26320211
46	Acetylation	PKHAAYRKYTEQITN CCCHHHHHHHHHHHH	43.79	23576753
55	Acetylation	TEQITNEKLDMVKAE HHHHHHHHHHCCCCC	52.43	24062335
60	Acetylation	NEKLDMVKAEPDVKK HHHHHCCCCCCCHHH	40.15	23864654
60	Succinylation	NEKLDMVKAEPDVKK HHHHHCCCCCCCHHH	40.15	26388266
66	Acetylation	VKAEPDVKKLEALLQ CCCCCCHHHHHHHHC	60.05	23864654
89	Phosphorylation	LQAEKELSLARKMLK HHHHHHHHHHHHHHC	22.52	23737553
93	Acetylation	KELSLARKMLKWKPW HHHHHHHHHHCCCCC	42.87	24062335
96	Acetylation	SLARKMLKWKPWEPL HHHHHHHCCCCCCCC	50.07	23864654
98	Succinylation	ARKMLKWKPWEPLVE HHHHHCCCCCCCCCC	38.37	-
98	Acetylation	ARKMLKWKPWEPLVE HHHHHCCCCCCCCCC	38.37	23576753
98	Succinylation	ARKMLKWKPWEPLVE HHHHHCCCCCCCCCC	38.37	23806337

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NDUA5_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
98	K	Acetylation		23806337
Acetylation of Lys-98 is observed in liver mitochondria from fasted mice but not from fed mice.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NDUA5_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of NDUA5_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NDUA5_MOUSE

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Substrate and functional diversity of lysine acetylation revealed bya proteomics survey."; Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T.,Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.; Mol. Cell 23:607-618(2006). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-36; LYS-46 AND LYS-98, ANDMASS SPECTROMETRY.	16916647 [Abstract]