dbPTM

NDUA2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NDUA2_MOUSE
UniProt AC	Q9CQ75
Protein Name	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
Gene Name	Ndufa2
Organism	Mus musculus (Mouse).
Sequence Length	99
Subcellular Localization	Mitochondrion inner membrane Peripheral membrane protein Matrix side .
Protein Description	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone..
Protein Sequence	MAAAAASRAVGAKLGLREIRVHLCQRSPGSQGVRDFIVQRYVELKKAHPNLPILIRECSEVQPKLWARYAFGQEKTVSLNNLSADEVTRAMQNVLSGKA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAAAASRA ------CHHHHHHHH	13.05	-
13	Acetylation	ASRAVGAKLGLREIR HHHHHHHHHCCCCHH	36.84	23864654
13	Malonylation	ASRAVGAKLGLREIR HHHHHHHHHCCCCHH	36.84	26320211
24	S-nitrosocysteine	REIRVHLCQRSPGSQ CCHHHHHHHCCCCCH	1.58	-
24	S-nitrosylation	REIRVHLCQRSPGSQ CCHHHHHHHCCCCCH	1.58	21278135
58	S-nitrosocysteine	LPILIRECSEVQPKL CCEEEEECCCCCHHH	2.78	-
58	S-nitrosylation	LPILIRECSEVQPKL CCEEEEECCCCCHHH	2.78	21278135
64	Acetylation	ECSEVQPKLWARYAF ECCCCCHHHHHHHHH	39.30	23576753
64	Succinylation	ECSEVQPKLWARYAF ECCCCCHHHHHHHHH	39.30	-
64	Succinylation	ECSEVQPKLWARYAF ECCCCCHHHHHHHHH	39.30	23806337
75	Acetylation	RYAFGQEKTVSLNNL HHHHCCCCEEECCCC	46.46	23576753
75	Succinylation	RYAFGQEKTVSLNNL HHHHCCCCEEECCCC	46.46	26388266
76	Phosphorylation	YAFGQEKTVSLNNLS HHHCCCCEEECCCCC	17.99	27742792
78	Phosphorylation	FGQEKTVSLNNLSAD HCCCCEEECCCCCHH	30.52	25521595
83	Phosphorylation	TVSLNNLSADEVTRA EEECCCCCHHHHHHH	35.48	29899451
98	Succinylation	MQNVLSGKA------ HHHHHCCCC------	47.77	26388266
98	Acetylation	MQNVLSGKA------ HHHHHCCCC------	47.77	23576753

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NDUA2_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
64	K	Acetylation	23806337
Acetylation of Lys-64 and Lys-75 is observed in liver mitochondria from fasted mice but not from fed mice.
75	K	Acetylation	23576753
Acetylation of Lys-64 and Lys-75 is observed in liver mitochondria from fasted mice but not from fed mice.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NDUA2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of NDUA2_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NDUA2_MOUSE

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Substrate and functional diversity of lysine acetylation revealed bya proteomics survey."; Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T.,Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.; Mol. Cell 23:607-618(2006). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-64 AND LYS-75, AND MASSSPECTROMETRY.	16916647 [Abstract]