| UniProt ID | NDRG2_RAT | |
|---|---|---|
| UniProt AC | Q8VBU2 | |
| Protein Name | Protein NDRG2 | |
| Gene Name | Ndrg2 | |
| Organism | Rattus norvegicus (Rat). | |
| Sequence Length | 371 | |
| Subcellular Localization | Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone. In neurons, seems to concentrate at axonal growth cone. | |
| Protein Description | Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor (By similarity). May be involved in dendritic cell and neuron differentiation.. | |
| Protein Sequence | MAELQEVQITEEKPLLPGQTPEAAKEAELAARILLDQGQTHSVETPYGSVTFTVYGTPKPKRPAIFTYHDVGLNYKSCFQPLFQFGDMQEIIQNFVRVHVDAPGMEEGAPVFPLGYQYPSQDQLADMIPCILQYLNFSTIIGVGVGAGAYILSRYALNHPDTVEGLVLINIDPNAKGWMDWAAHKLTGLTSSIPEMILGHLFSQEELSGNSELIQKYRSLITHAPNLENIELYWNSYNNRRDLNFERGGEMTLKCPVMLVVGDQAPHEDAVVECNSKLDPTQTSFLKMADSGGQPQLTQPGKLTEAFKYFVQGMGYMASSCMTRLSRSRTASLTSAASIDGSRSRSRTLSQSSESGTLPSGPPGHTMEVSC | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MAELQEVQI ------CCCCEEEEE | 26.63 | - | |
| 10 | Phosphorylation | ELQEVQITEEKPLLP CCEEEEECCCCCCCC | 22.47 | 22673903 | |
| 13 | Acetylation | EVQITEEKPLLPGQT EEEECCCCCCCCCCC | 34.43 | 22902405 | |
| 13 | Ubiquitination | EVQITEEKPLLPGQT EEEECCCCCCCCCCC | 34.43 | - | |
| 20 | Phosphorylation | KPLLPGQTPEAAKEA CCCCCCCCHHHHHHH | 29.07 | 22673903 | |
| 47 | Phosphorylation | THSVETPYGSVTFTV CEEEECCCEEEEEEE | 29.47 | - | |
| 49 | Phosphorylation | SVETPYGSVTFTVYG EEECCCEEEEEEEEC | 16.49 | - | |
| 55 | Phosphorylation | GSVTFTVYGTPKPKR EEEEEEEECCCCCCC | 16.54 | - | |
| 61 | Acetylation | VYGTPKPKRPAIFTY EECCCCCCCCEEEEE | 76.71 | 22902405 | |
| 326 | Phosphorylation | SSCMTRLSRSRTASL HHHHHHHHHCCCCCC | 25.56 | 21738781 | |
| 328 | Phosphorylation | CMTRLSRSRTASLTS HHHHHHHCCCCCCCC | 30.52 | 28825834 | |
| 330 | Phosphorylation | TRLSRSRTASLTSAA HHHHHCCCCCCCCCH | 23.11 | 28825834 | |
| 332 | Phosphorylation | LSRSRTASLTSAASI HHHCCCCCCCCCHHC | 31.41 | 19700791 | |
| 334 | Phosphorylation | RSRTASLTSAASIDG HCCCCCCCCCHHCCC | 17.52 | 28825834 | |
| 335 | Phosphorylation | SRTASLTSAASIDGS CCCCCCCCCHHCCCC | 27.42 | 28825834 | |
| 338 | Phosphorylation | ASLTSAASIDGSRSR CCCCCCHHCCCCCCC | 22.41 | 28825834 | |
| 342 | Phosphorylation | SAASIDGSRSRSRTL CCHHCCCCCCCCCCC | 24.28 | 28689409 | |
| 344 | Phosphorylation | ASIDGSRSRSRTLSQ HHCCCCCCCCCCCCC | 35.98 | 29779826 | |
| 346 | Phosphorylation | IDGSRSRSRTLSQSS CCCCCCCCCCCCCCC | 30.75 | 21738781 | |
| 348 | Phosphorylation | GSRSRSRTLSQSSES CCCCCCCCCCCCCCC | 31.82 | 28825834 | |
| 350 | Phosphorylation | RSRSRTLSQSSESGT CCCCCCCCCCCCCCC | 27.66 | 28825834 | |
| 352 | Phosphorylation | RSRTLSQSSESGTLP CCCCCCCCCCCCCCC | 32.47 | 28825834 | |
| 353 | Phosphorylation | SRTLSQSSESGTLPS CCCCCCCCCCCCCCC | 28.30 | 28825834 | |
| 355 | Phosphorylation | TLSQSSESGTLPSGP CCCCCCCCCCCCCCC | 38.74 | 27097102 | |
| 357 | Phosphorylation | SQSSESGTLPSGPPG CCCCCCCCCCCCCCC | 44.78 | 27097102 | |
| 360 | Phosphorylation | SESGTLPSGPPGHTM CCCCCCCCCCCCCCE | 68.02 | 27097102 | |
| 366 | Phosphorylation | PSGPPGHTMEVSC-- CCCCCCCCEEEEC-- | 22.42 | 27097102 | |
| 370 | Phosphorylation | PGHTMEVSC------ CCCCEEEEC------ | 10.78 | 27097102 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 332 | S | Phosphorylation | Kinase | PRKCQ | Q02111 | GPS |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NDRG2_RAT !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NDRG2_RAT !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of NDRG2_RAT !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Phosphoproteomic analysis of rat liver by high capacity IMAC and LC-MS/MS."; Moser K., White F.M.; J. Proteome Res. 5:98-104(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-332 AND SER-338, ANDMASS SPECTROMETRY. | |
| "Akt mediates insulin-stimulated phosphorylation of Ndrg2: evidencefor cross-talk with protein kinase C theta."; Burchfield J.G., Lennard A.J., Narasimhan S., Hughes W.E.,Wasinger V.C., Corthals G.L., Okuda T., Kondoh H., Biden T.J.,Schmitz-Peiffer C.; J. Biol. Chem. 279:18623-18632(2004). Cited for: IDENTIFICATION BY MASS SPECTROMETRY (ISOFORM 1), AND PHOSPHORYLATIONAT SER-332. | |
