NDKA_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDKA_RAT
• UniProt AC: Q05982
• Protein Name: Nucleoside diphosphate kinase A
• Gene Name: Nme1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 152
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair (By similarity)..
• Protein Sequence: MANSERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFIQASEDLLKEHYIDLKDRPFFSGLVKYMHSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVESAEKEISLWFQPEELVDYKSCAQNWIYE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Ubiquitination	ERTFIAIKPDGVQRG CCEEEEECCCCHHCC	28.21	-
12	Acetylation	ERTFIAIKPDGVQRG CCEEEEECCCCHHCC	28.21	22638563
26	Acetylation	GLVGEIIKRFEQKGF CHHHHHHHHHHHCCC	57.61	8275629
31	Acetylation	IIKRFEQKGFRLVGL HHHHHHHCCCEEEEE	53.47	134721
49	Ubiquitination	QASEDLLKEHYIDLK CCCHHHHHHCCCCCC	50.14	-
49	Acetylation	QASEDLLKEHYIDLK CCCHHHHHHCCCCCC	50.14	22902405
56	Acetylation	KEHYIDLKDRPFFSG HHCCCCCCCCCCHHH	48.20	22902405
56	Ubiquitination	KEHYIDLKDRPFFSG HHCCCCCCCCCCHHH	48.20	-
62	Phosphorylation	LKDRPFFSGLVKYMH CCCCCCHHHHHHHHH	31.43	23984901
94	Phosphorylation	GRVMLGETNPADSKP CCEEECCCCCCCCCC	44.71	23991683
99	Phosphorylation	GETNPADSKPGTIRG CCCCCCCCCCCCCCC	42.74	27097102
100	Acetylation	ETNPADSKPGTIRGD CCCCCCCCCCCCCCC	48.27	7618839
103	Phosphorylation	PADSKPGTIRGDFCI CCCCCCCCCCCCEEE	18.94	23991683
120	Phosphorylation	GRNIIHGSDSVESAE CCCEEECCCCHHHHH	16.73	23991683
122	Phosphorylation	NIIHGSDSVESAEKE CEEECCCCHHHHHHH	29.49	23991683
125	Phosphorylation	HGSDSVESAEKEISL ECCCCHHHHHHHEEC	39.30	23991683
128	Ubiquitination	DSVESAEKEISLWFQ CCHHHHHHHEECCCC	61.13	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
94	T	Phosphorylation	Kinase	CDK1	P06493	PSP
120	S	Phosphorylation	Kinase	CDK1	P06493	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NDKA_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDKA_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of NDKA_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.