dbPTM

NCTR1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NCTR1_HUMAN
UniProt AC	O76036
Protein Name	Natural cytotoxicity triggering receptor 1
Gene Name	NCR1
Organism	Homo sapiens (Human).
Sequence Length	304
Subcellular Localization	Cell membrane Single-pass type I membrane protein .
Protein Description	Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis..
Protein Sequence	MSSTLPALLCVGLCLSQRISAQQQTLPKPFIWAEPHFMVPKEKQVTICCQGNYGAVEYQLHFEGSLFAVDRPKPPERINKVKFYIPDMNSRMAGQYSCIYRVGELWSEPSNLLDLVVTEMYDTPTLSVHPGPEVISGEKVTFYCRLDTATSMFLLLKEGRSSHVQRGYGKVQAEFPLGPVTTAHRGTYRCFGSYNNHAWSFPSEPVKLLVTGDIENTSLAPEDPTFPADTWGTYLLTTETGLQKDHALWDHTAQNLLRMGLAFLVLVALVWFLVEDWLSRKRTRERASRASTWEGRRRLNTQTL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
84	Phosphorylation	RINKVKFYIPDMNSR HHCEEEEEECCCCHH	13.06	24719451
90	Phosphorylation	FYIPDMNSRMAGQYS EEECCCCHHHCCEEE	19.45	24719451
216	N-linked_Glycosylation	LVTGDIENTSLAPED EEECCCCCCCCCCCC	34.99	UniProtKB CARBOHYD
292	Phosphorylation	ERASRASTWEGRRRL HHHHHHHHHHHHHHC	26.93	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NCTR1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NCTR1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NCTR1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
CD3Z_HUMAN	CD247	physical	9625766
CD59_HUMAN	CD59	physical	14635045

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NCTR1_HUMAN

Related Literatures of Post-Translational Modification